Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

Potassium channels are widespread over all kingdoms and play an important role in the
maintenance of cellular ionic homeostasis. Kv1. 3 is a voltage-gated potassium channel of …

Abstract The potassium channel Kv1. 3, involved in several important pathologies, is the
target of a family of psoralen-based drugs whose mechanism of action is not fully …

HIGHLIGHTS Computational techniques provide accurate descriptions of the structure and
dynamics of biological systems, contributing to their understanding at an atomic level …

The use of computers for predicting the structures and properties of biomolecules has
closely paralleled computer development since the 1950s, and has been one of the core …

Cancer is the consequence of aberrations in cell growth or cell death. In this scenario,
mitochondria and ion channels play a critical role in regard to cell proliferation, malignant …

Potassium channels are of paramount physiological and pathological importance and
therefore constitute significant drug targets. One of the keys to rationalize the way drugs …

We have prepared three alkaloids from the Agelas sponges, clathrodin, hymenidin and
oroidin, and a series of their synthetic analogues, and evaluated their inhibitory effect …

The voltage‐dependent potassium channel Kv1. 3 has been implicated in proliferation in
many cell types, based on the observation that Kv1. 3 blockers inhibited proliferation. By …

Methotrexate (MTX) has been widely used for the treatment of many types of autoimmune
diseases, such as rheumatoid arthritis, psoriasis and dermatomyositis. However, its …