A backpack-based myeloid cell therapy for multiple sclerosis

N Kapate, M Dunne, N Kumbhojkar… - Proceedings of the …, 2023 - National Acad Sciences
Multiple sclerosis (MS) is an incurable autoimmune disease and is currently treated by
systemic immunosuppressants with off-target side effects. Although aberrant myeloid …

Recent advancements in nanoparticle-mediated approaches for restoration of multiple sclerosis

N Rahiman, M Mohammadi, SH Alavizadeh… - Journal of Controlled …, 2022 - Elsevier
Multiple Sclerosis (MS) is an autoimmune disease with complicated immunopathology
which necessitates considering multifactorial aspects for its management. Nano-sized …

Interleukin-6: evolving role in the management of neuropathic pain in neuroimmunological disorders

K Serizawa, H Tomizawa-Shinohara, S Miyake… - Inflammation and …, 2021 - Springer
Background Neuropathic pain in neuroimmunological disorders refers to pain caused by a
lesion or disease of the somatosensory system such as multiple sclerosis (MS) and …

Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis

A Montilla, A Zabala, M Er-Lukowiak, B Rissiek… - Cell Death & …, 2023 - nature.com
In multiple sclerosis and the experimental autoimmune encephalomyelitis (EAE) model, both
resident microglia and infiltrating macrophages contribute to demyelination as well as …

Synthesis and comprehensive in vivo activity profiling of olean-12-en-28-ol, 3β-pentacosanoate in experimental autoimmune encephalomyelitis: a natural …

H Senol, O Ozgun-Acar, A Dag, A Eken… - Journal of Natural …, 2023 - ACS Publications
Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain
cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate …

Piperine improves experimental autoimmune encephalomyelitis (EAE) in lewis rats through its neuroprotective, anti-inflammatory, and antioxidant effects

R Nasrnezhad, S Halalkhor, F Sadeghi… - Molecular …, 2021 - Springer
Inflammation, demyelination, glial activation, and oxidative damage are the most
pathological hallmarks of multiple sclerosis (MS). Piperine, a main bioactive alkaloid of black …

Cathelicidin antimicrobial peptide expression in neutrophils and neurons antagonistically modulates neuroinflammation

SC Verma, E Enée, K Manasse, F Rebhi, A Penc… - The Journal of Clinical …, 2024 - jci.org
Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system
(CNS), the pathophysiology of which remains unclear and for which there is no definitive …

[HTML][HTML] GPX4 aggravates experimental autoimmune encephalomyelitis by inhibiting the functions of CD4+ T cells

H Li, Y Zeng, S Luo, Z Li, F Huang, Z Liu - Biochemical and Biophysical …, 2023 - Elsevier
Multiple sclerosis (MS) is a common autoimmunity disease of the central nervous system
(CNS) that mostly happens in young adults. The chronic clinical features of MS include …

The fluctuations of expression profiles of critical genes in the miRNA maturation process and pro-and anti-inflammatory cytokines in the pathogenesis and progression …

F Khakdan, AS Javanmard, P Shahmoradipour… - Molecular Biology …, 2023 - Springer
Background Multiple sclerosis (MS) is a central nervous system disease known for immune-
mediated demyelination, inflammatory, and neurodegeneration symptoms. Discovering …

Tehranolid and artemisinin effects on ameliorating experimental autoimmune encephalomyelitis by modulating inflammation and remyelination

N Salehi, M Nourbakhsh, S Noori, H Rezaeizadeh… - Molecular …, 2023 - Springer
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous
system. Artemisinin (ART) is a natural sesquiterpene lactone with an endoperoxide bond …