The multiple mechanisms that regulate p53 activity and cell fate
A Hafner, ML Bulyk, A Jambhekar… - Nature reviews Molecular …, 2019 - nature.com
The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
AN Blackford, SP Jackson - Molecular cell, 2017 - cell.com
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-
wide screens in human cells,–. Whereas some cell types are amenable to genome …
wide screens in human cells,–. Whereas some cell types are amenable to genome …
METTL3 and N6-methyladenosine promote homologous recombination-mediated repair of DSBs by modulating DNA-RNA hybrid accumulation
C Zhang, L Chen, D Peng, A Jiang, Y He, Y Zeng… - Molecular cell, 2020 - cell.com
Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired,
may lead to genome instability or cell death. Here, we report that, in response to DSBs, the …
may lead to genome instability or cell death. Here, we report that, in response to DSBs, the …
DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities
Y Abuetabh, HH Wu, C Chai, H Al Yousef… - … & molecular medicine, 2022 - nature.com
Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …
DNA-repair defects and olaparib in metastatic prostate cancer
Background Prostate cancer is a heterogeneous disease, but current treatments are not
based on molecular stratification. We hypothesized that metastatic, castration-resistant …
based on molecular stratification. We hypothesized that metastatic, castration-resistant …
[HTML][HTML] ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation
Novel approaches are needed to boost the efficacy of immune checkpoint blockade (ICB)
therapy. Ataxia telangiectasia mutated (ATM) protein plays a central role in sensing DNA …
therapy. Ataxia telangiectasia mutated (ATM) protein plays a central role in sensing DNA …
Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signaling after nuclear DNA damage
G Dunphy, SM Flannery, JF Almine, DJ Connolly… - Molecular cell, 2018 - cell.com
DNA damage can be sensed as a danger-associated molecular pattern by the innate
immune system. Here we find that keratinocytes and other human cells mount an innate …
immune system. Here we find that keratinocytes and other human cells mount an innate …
Metalloimmunology: The metal ion-controlled immunity
Metals are essential components in all forms of life required for the function of nearly half of
all enzymes and are critically involved in virtually all fundamental biological processes …
all enzymes and are critically involved in virtually all fundamental biological processes …
Hydrogen peroxide–production, fate and role in redox signaling of tumor cells
C Lennicke, J Rahn, R Lichtenfels… - Cell communication and …, 2015 - Springer
Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …