CONTEXT: In 2005, fusions between the androgen-regulated transmembrane protease
serine 2 gene, TMPRSS2, and E twenty-six (ETS) transcription factors were discovered in …

Chromosomal rearrangements that result in high level expression of ETS gene family
members are common events in human prostate cancer. Most frequently, the androgen …

TMPRSS2-ERG gene fusions are the predominant molecular subtype of prostate cancer.
Here, we explored the role of TMPRSS2-ERG gene fusion product using in vitro and in vivo …

Computational methods for image-based profiling are under active development, but their
success hinges on assays that can capture a wide range of phenotypes. We have …

Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription
factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to …

BCOR-CCNB3 fusion transcripts resulting from an X-chromosomal paracentric inversion
were recently identified in a series of unclassifiable soft tissue and bone sarcomas with …

Multi-parameter phenotypic profiling of small molecules provides important insights into their
mechanisms of action, as well as a systems level understanding of biological pathways and …

Purpose: Ewing sarcoma is a pediatric bone tumor that absolutely relies on the
transcriptional activity of the EWS/ETS family of fusion oncoproteins. While the most common …

In the US, approximately 650 children are diagnosed with osteosarcoma and Ewing
sarcoma (ES) each year. Five‐year survival ranges from 65% to 75% for localized disease …

The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born
with the disease each year in Africa alone. Induction of fetal hemoglobin is a validated …