The rOX‐stars of inflammation: links between the inflammasome and mitochondrial meltdown

CL Holley, K Schroder - Clinical & translational immunology, 2020 - Wiley Online Library
The nod‐like receptor protein 3 (NLRP3) inflammasome drives inflammation in response to
mitochondrial dysfunction. As metabolic powerhouses with prokaryotic ancestry …

Parkin, an E3 ubiquitin ligase, enhances airway mitochondrial DNA release and inflammation

KG Dimasuay, N Schaunaman, RJ Martin, N Pavelka… - Thorax, 2020 - thorax.bmj.com
Introduction Parkin (Park2), an E3 ubiquitin ligase, is critical to maintain mitochondrial
function by regulating mitochondrial biogenesis and degradation (mitophagy), but recent …