Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics

J Saarbach, PM Sabale, N Winssinger - Current opinion in chemical …, 2019 - Elsevier
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide
mimetics. Salient features include the stability of hybridization complexes (either as …

Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications

C Suparpprom, T Vilaivan - RSC Chemical Biology, 2022 - pubs.rsc.org
Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …

Orthogonal amplification circuits composed of acyclic nucleic acids enable RNA detection

Y Chen, R Nagao, K Murayama… - Journal of the American …, 2022 - ACS Publications
Construction of complex DNA circuits is difficult due to unintended hybridization and
degradation by enzymes under biological conditions. We herein report a hybridization chain …

Supernatural: Artificial Nucleobases and Backbones to Program Hybridization-Based Assemblies and Circuits

M Lopez-Tena, SK Chen, N Winssinger - Bioconjugate Chemistry, 2022 - ACS Publications
The specificity and predictability of hybridization make oligonucleotides a powerful platform
to program assemblies and networks with logic-gated responses, an area of research which …

8-Pyrenylvinyl adenine controls reversible duplex formation between serinol nucleic acid and RNA by [2+ 2] Photocycloaddition

K Murayama, Y Yamano… - Journal of the American …, 2019 - ACS Publications
Photocontrol of duplex formation between the totally artificial serinol nucleic acid (SNA) and
target RNA was made possible using a photoresponsive nucleobase 8-pyrenylvinyl adenine …

Integration of chemically modified nucleotides with DNA strand displacement reactions for applications in living systems

AM Kabza, N Kundu, W Zhong… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Watson–Crick base pairing rules provide a powerful approach for engineering DNA‐based
nanodevices with programmable and predictable behaviors. In particular, DNA strand …

Kinetics of Strand Displacement Reaction with Acyclic Artificial Nucleic Acids

K Makino, I Sugiyama, H Asanuma… - Angewandte Chemie …, 2024 - Wiley Online Library
Toehold‐mediated strand displacement (TMSD) reaction, one of the DNA nanotechnologies,
has great potential as s biological programmable platform in the cellular environment …

Development of the Right-and Left-Handed Gamma Peptide Nucleic Acid Building Blocks for On-Resin Chemical Functionalization

I Dhami, SA Thadke, DH Ly - The Journal of Organic Chemistry, 2022 - ACS Publications
Gamma peptide nucleic acids (PNAs) are a promising class of nucleic acid mimics that
adopt either a right-or left-handed helical motif as individual strands and hybridize to DNA or …

Impact of charges on the hybridization kinetics and thermal stability of PNA duplexes

M López-Tena, N Winssinger - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
Peptide nucleic acid (PNA) is prominent artificial nucleic acid mimetic and modifications at
the-position of the peptidic backbone are known to further enhance the desirable …

Functionalization of acyclic xenonucleic acid with modified nucleobases

K Murayama, Y Yamano, H Asanuma - Polymer Journal, 2023 - nature.com
Xenonucleic acids (XNAs), which are composed of artificial scaffolds and natural
nucleobases, have unique hybridization properties that depend on the scaffold structure …