The repair and functional reconstruction of bone defects resulting from severe trauma,
surgical resection, degenerative disease, and congenital malformation pose significant …

The treatment of bone defects remains a challenging clinical problem with high
reintervention rates, morbidity, and resulting significant healthcare costs. Surgical …

Regeneration of severe bone defects remains an enormous challenge in clinic. Developing
regenerative scaffolds to directionally guide bone growth is a potential strategy to overcome …

Bone fusion of defect broken ends is the basis of the functional reconstruction of critical
maxillofacial segmental bone defects. However, the currently available treatments do not …

Objectives Delivery systems that provide time and space control have a good application
prospect in tissue regeneration applications, as they can effectively improve the process of …

Patients suffering diabetic bone defects still need some new and effective strategies to
achieve enhanced prognostic effects. Although medical implants are the common treatment …

Over eight million surgical procedures are conducted annually in the United States to
address organ failures or tissue losses. In response to this pressing need, recent medical …

This study reports for first time the development of bone-regenerative nanocomposite
microspheres re-engineered from chicken eggs. We deployed a novel hybrid crosslinking …

The regenerative repair of segmental bone defect (SBD) is an urgent problem in the field of
orthopedics. Rapid induction of angiogenesis and osteoinductivity after implantation of …

Bone extracellular matrix (ECM) has been shown to mimic aspects of the tissue's complex
microenvironment, suggesting its potential role in promoting bone repair. However, current …