Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
Advancing models of neural development with biomaterials
Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …
[HTML][HTML] Complex oscillatory waves emerging from cortical organoids model early human brain network development
Structural and transcriptional changes during early brain maturation follow fixed
developmental programs defined by genetics. However, whether this is true for functional …
developmental programs defined by genetics. However, whether this is true for functional …
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease
Alzheimer's disease (AD) is characterized by beta-amyloid accumulation, phosphorylated
tau formation, hyperactivation of glial cells, and neuronal loss. The mechanisms of AD …
tau formation, hyperactivation of glial cells, and neuronal loss. The mechanisms of AD …
Fusion of regionally specified hPSC-derived organoids models human brain development and interneuron migration
Organoid techniques provide unique platforms to model brain development and
neurological disorders. Whereas several methods for recapitulating corticogenesis have …
neurological disorders. Whereas several methods for recapitulating corticogenesis have …
Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures
Investigating human oligodendrogenesis and the interaction of oligodendrocytes with
neurons and astrocytes would accelerate our understanding of the mechanisms underlying …
neurons and astrocytes would accelerate our understanding of the mechanisms underlying …
The ASD Living Biology: from cell proliferation to clinical phenotype
E Courchesne, T Pramparo, VH Gazestani… - Molecular …, 2019 - nature.com
Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the
lay public because of its uncertain origins and striking and unexplained clinical …
lay public because of its uncertain origins and striking and unexplained clinical …
Directing induced pluripotent stem cell derived neural stem cell fate with a three-dimensional biomimetic hydrogel for spinal cord injury repair
L Fan, C Liu, X Chen, Y Zou, Z Zhou, C Lin… - … applied materials & …, 2018 - ACS Publications
Current treatment approaches for spinal cord injuries (SCIs) are mainly based on cellular
transplantation. Induced pluripotent stem cells (iPSCs) without supply constraints and ethical …
transplantation. Induced pluripotent stem cells (iPSCs) without supply constraints and ethical …
Exosomes regulate neurogenesis and circuit assembly
Exosomes are thought to be released by all cells in the body and to be involved in
intercellular communication. We tested whether neural exosomes can regulate the …
intercellular communication. We tested whether neural exosomes can regulate the …
Hydrogel systems and their role in neural tissue engineering
P Madhusudanan, G Raju… - Journal of the Royal …, 2020 - royalsocietypublishing.org
Neural tissue engineering (NTE) is a rapidly progressing field that promises to address
several serious neurological conditions that are currently difficult to treat. Selecting the right …
several serious neurological conditions that are currently difficult to treat. Selecting the right …