The present state of ion-pair chromatography (IPC) is reviewed. Emphasis is placed on the
theoretical modeling of the retention behavior of charged, zwitterionic, and neutral solutes …

The introduction of synthetic nicotine by the tobacco industry, also promoted as tobacco-free
nicotine, presented new challenges for analytical chemists working in tobacco regulatory …

The enantiomeric composition of nicotine in 18 smokeless tobaccos, 3 strains of tobacco
leaf, 8 pharmaceutical products, and 4 commercial reagents was determined. The relative …

Recently, a variety of new tobacco‐free‐nicotine, TFN, products have been commercialized
as e‐liquids. Tobacco‐derived nicotine contains predominantly (S)‐(−)‐nicotine, whereas …

This review gives a brief overview over the major aspects of application of the nicotine
alkaloid and its close derivatives in the therapy of some neurodegenerative disorders and …

The predominant enantiomer of nicotine found in nature is (S)-nicotine and its pharmacology
has been widely established. However, pharmacologic information concerning individual …

Abstract Nʹ-Nitrosonornicotine (NNN), a carcinogenic tobacco-specific Nʹ-nitrosamine
(TSNA), is on the FDA list of harmful and potentially harmful constituents (HPHCs) …

Many organisms possess “secondary” compounds to avoid consumption or to immobilize
prey. While the most abundant or active compounds are initially investigated, more …

Evaluating the source of nicotine in e‐liquid is a problem. Tobacco‐derived nicotine
contains predominantly (S)‐(−)‐nicotine, whereas tobacco‐free nicotine products may not …

A dramatic and beneficial effect of ethanesulfonic acid (ESA) on the chiral HPLC separation
of basic compounds was found. Using a single chiral column and a starting mobile phase …