The idea that predictions shape how we perceive and comprehend the world has become
increasingly influential in the field of systems neuroscience. It also forms an important …

A host of learning, memory, and decision-making processes form the individual's response
to threat and may be disrupted in anxiety and post-trauma psychopathology. Here we review …

Previous research has stressed the importance of uncertainty for controlling the speed of
learning, and how such control depends on the learner inferring the noise properties of the …

The very earliest stages of sensory processing have the potential to alter how we perceive
and respond to our environment. These initial processing circuits can incorporate subcortical …

Threat conditioning is a laboratory model of associative learning across species that is often
used in research on the etiology and treatment of anxiety disorders. At least 10 different …

Safety learning occurs when an otherwise neutral stimulus comes to signal the absence of
threat, allowing organisms to use safety information to inhibit fear and anxiety in …

Laboratory experiments using fear conditioning and extinction protocols help lay the
groundwork for designing, testing, and optimizing innovative treatments for anxiety-related …

Transactive response DNA-binding protein 43 kDa (TDP-43) was identified as a major
disease-associated component in the brain of patients with amyotrophic lateral sclerosis …

The amygdala is a core component in neurobiological models of stress and stress-related
pathologies, including post-traumatic stress disorder (PTSD). While numerous studies have …

A serious lack of effective pharmacotherapeutic interventions for posttraumatic stress
disorder (PTSD) raises the urgent need for the development of novel treatments. Ketamine …