Hyaluronic acid (HA) is a natural polymer, produced endogenously by the human body,
which has unique physicochemical and biological properties, exhibiting desirable …

CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …

Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated
synthesis and degradation of HA modulates the ECM chemical and physical properties that …

Hyaluronic acid (HA) is a high molecular weight, non-sulfated anionic polysaccharide from
glycosamine glycan family. It is a versatile biomaterial that binds to specific cell receptor …

A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

Simple Summary Tumor stroma is known to significantly influence cancer initiation and
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …

CD44 is a cell matrix adhesion molecule overexpressed on the cell surfaces of the major
cancers. CD44 as a cancer-related biomarker has an essential role in the invasion and …

Nanoparticles (NPs) modified with targeting ligands have often shown great potential in
targeted drug delivery for tumor therapy. However, the clearance of NPs by the monocyte …

The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …

Monocytes circulate in the bloodstream, extravasate into the tissue and differentiate into
specific macrophage phenotypes to fulfill the immunological needs of tissues. During the …