The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. In
addition to cognitive deficits, FXS patients exhibit hyperactivity, attention deficits, social …

Colorectal cancer is the third most common cancer in males and second in females. This
disease can be caused by genetic and acquired/environmental factors. Microsatellite …

ABSTRACT Background Fragile X syndrome (FXS) is primarily due to CGG repeat
expansions in the FMR1 gene. FMR1 alleles are classified as normal (N), intermediate (I) …

The human genome segment upstream of the FMR1 (fragile X mental retardation 1) gene
(Xq27. 3) contains several genetic signals, among them is a DNA methylation boundary that …

Abstract Background Fragile X Syndrome (FXS), the most common inherited form of mental
retardation, is caused by expansion of a CGG/CCG repeat tract in the 5′-untranslated …

Although there have been many investigations into how trinucleotide repeats affect
nucleosome formation and local chromatin structure, the nucleosome positioning of GAA …

Trinucleotide repeat sequences (TRSs), consisting of 10 unique classes of repeats in DNA,
are members of microsatellites and abundantly and non-randomly distributed in many …

More than 30 human genetic diseases are linked to tri-nucleotide repeat expansions. There
is no known mechanism that explains repeat expansions in full, but changes in the …

Since the generation of the first transgenic animal by Gordan and Ruddle, several methods
and procedures have been developed for the manipulation of the genome. This chapter …