NAD metabolism in cancer therapeutics

K Yaku, K Okabe, K Hikosaka, T Nakagawa - Frontiers in oncology, 2018 - frontiersin.org
Cancer cells have a unique energy metabolism for sustaining rapid proliferation. The
preference for anaerobic glycolysis under normal oxygen conditions is a unique trait of …

PARP-1 involvement in neurodegeneration: a focus on Alzheimer's and Parkinson's diseases

S Martire, L Mosca, M d'Erme - Mechanisms of ageing and development, 2015 - Elsevier
DNA damage is the prime activator of the enzyme poly (ADP-ribose) polymerase1 (PARP-1)
whose overactivation has been proven to be associated with the pathogenesis of numerous …

NAD+ salvage pathway in cancer metabolism and therapy

BE Kennedy, T Sharif, E Martell, C Dai, Y Kim… - Pharmacological …, 2016 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme for various
physiological processes including energy metabolism, DNA repair, cell growth, and cell …

[HTML][HTML] Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals

A Alijagic, O Kotlyar, M Larsson, S Salihovic… - Environment …, 2024 - Elsevier
Due to their exceptional properties and cost effectiveness, polyamides or nylons have
emerged as widely used materials, revolutionizing diverse industries, including industrial 3D …

NMNAT2‐mediated NAD+ generation is essential for quality control of aged oocytes

X Wu, F Hu, J Zeng, L Han, D Qiu, H Wang, J Ge… - Aging cell, 2019 - Wiley Online Library
Advanced maternal age has been reported to impair oocyte quality; however, the underlying
mechanisms remain to be explored. In the present study, we identified the lowered NAD+ …

Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies

Y Zhu, J Liu, J Park, P Rai, RG Zhai - Pharmacology & therapeutics, 2019 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is an essential biomolecule involved in many
critical processes. Its role as both a driver of energy production and a signaling molecule …

The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions

C Fortunato, F Mazzola, N Raffaelli - IUBMB life, 2022 - Wiley Online Library
The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes a
reaction central to all known NAD biosynthetic routes. In mammals, three isoforms with …

Impact of NAD+ metabolism on ovarian aging

J Liang, F Huang, Z Song, R Tang, P Zhang, R Chen - Immunity & Ageing, 2023 - Springer
Abstract Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox
reactions, is closely associated with age-related functional degeneration and metabolic …

EGCG inhibits pressure overload‐induced cardiac hypertrophy via the PSMB5/Nmnat2/SIRT6‐dependent signalling pathways

Y Cai, SS Yu, Y He, XY Bi, S Gao, TD Yan… - Acta …, 2021 - Wiley Online Library
Abstract Aim Epigallocatechin‐3‐gallate (EGCG), the major polyphenol found in green tea,
exerts multiple protective effects against cardiovascular diseases, including cardiac …

The NAD+ salvage pathway modulates cancer cell viability via p73

T Sharif, DG Ahn, RZ Liu, E Pringle, E Martell… - Cell Death & …, 2016 - nature.com
The involvement of the nicotinamide adenine dinucleotide (NAD+) salvage pathway in
cancer cell survival is poorly understood. Here we show that the NAD+ salvage pathway …