Anti-tuberculosis treatment strategies and drug development: challenges and priorities
VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …
biological uncertainties remain and hamper progress. However, owing to collaborative …
Reframing antimicrobial resistance as a continuous spectrum of manifestations
SM Schrader, H Botella, J Vaubourgeix - Current Opinion in Microbiology, 2023 - Elsevier
To fight antimicrobial resistance (AMR), we must recognize and target all its manifestations.
In this review, we briefly summarize the history that led to recognition of the various …
In this review, we briefly summarize the history that led to recognition of the various …
Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis
Antibiotic resistance of Mycobacterium tuberculosis is exclusively a consequence of
chromosomal mutations. Translesion synthesis (TLS) is a widely conserved mechanism of …
chromosomal mutations. Translesion synthesis (TLS) is a widely conserved mechanism of …
A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in …
WL Ng, EH Rego - Msphere, 2024 - Am Soc Microbiol
Antibiotic resistance in Mycobacterium tuberculosis exclusively originates from
chromosomal mutations, either during normal DNA replication or under stress, when the …
chromosomal mutations, either during normal DNA replication or under stress, when the …
[HTML][HTML] RecA-NT homology motif in ImuB is essential for mycobacterial ImuA'-ImuB protein interaction and mutasome function
JA Santos, K Timinskas, MH Lamers, Č Venclovas… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The mycobacterial mutasome–minimally comprising ImuA', ImuB, and DnaE2 proteins–has
been implicated in DNA damage-induced mutagenesis in Mycobacterium tuberculosis …
been implicated in DNA damage-induced mutagenesis in Mycobacterium tuberculosis …