Advances in IKBKE as a potential target for cancer therapy

M Yin, X Wang, J Lu - Cancer medicine, 2020 - Wiley Online Library
IKBKE (inhibitor of nuclear factor kappa‐B kinase subunit epsilon), a member of the
nonclassical IKK family, plays an important role in the regulation of inflammatory reactions …

Sanguinarine inhibition of TNF-α-induced CCL2, IKBKE/NF-κB/ERK1/2 signaling pathway, and cell migration in human triple-negative breast cancer cells

SS Messeha, NO Zarmouh, L Antonie… - International Journal of …, 2022 - mdpi.com
Angiogenesis is a process that drives breast cancer (BC) progression and metastasis, which
is linked to the altered inflammatory process, particularly in triple-negative breast cancer …

Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer

RT Bishop, S Marino, D de Ridder, RJ Allen, DV Lefley… - Cancer letters, 2019 - Elsevier
IκB kinase subunit epsilon (IKKε), a key component of NFκB and interferon signalling, has
been identified as a breast cancer oncogene. Here we report that the IKKε/TBK1 axis plays a …

[HTML][HTML] DDX3X functionally and physically interacts with Estrogen Receptor-alpha

J Pardeshi, N McCormack, L Gu, CS Ryan… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Abstract DEAD-box protein 3X (DDX3X) is a human DEAD-box protein with conventional
roles in RNA metabolism and unconventional functions in signalling pathways that do not …

Silencing IKBKE inhibits the migration and invasion of glioblastoma by promoting Snail1 degradation

Y Liu, G Guo, Y Lu, X Chen, L Zhu, L Zhao, C Li… - Clinical and …, 2022 - Springer
Purpose Glioblastoma multiforme (GBM) is one of the most common malignant brain tumors
in adults and has high mortality and relapse rates. Over the past few years, great advances …

Molecular mechanism of gossypol mediating CCL2 and IL‑8 attenuation in triple‑negative breast cancer cells

SS Messeha, NO Zarmouh… - Molecular …, 2020 - spandidos-publications.com
Chronic inflammation associated with cancer is characterized by the production of different
types of chemokines and cytokines. In cancer, numerous signaling pathways upregulate the …

[PDF][PDF] Immunohistochemical study of FoxA1 in Invasive Duct Carcinoma of the Breast and Corresponding Lymph Node Metastasis

AM Abelzaher, ME Abdelghany, HM Tawfiq… - Minia Journal of …, 2020 - journals.ekb.eg
FoxA1 (forkhead box protein A1) is one of three members in the FoxA related family
(forkhead family of transcriptions factors). FoxA related family proteins are often termed …

[PDF][PDF] Pharmacological inhibition of the IKK/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer

RT Bishopa, S Marinoa, D de Riddera, RJ Allena… - academia.edu
The nuclear factor-κB (NFκB) signaling is implicated in inflammation and cancer [1-5]. IB
kinase subunit epsilon (IKK), a key component of NF B signalling, has been identified as a …

[PDF][PDF] Immunohistochemical study of FoxA1 in Invasive Duct Carcinoma of the Breast and Corresponding Lymph Node Metastasis

HM Tawfiq, WF Aref - academia.edu
FoxA1 (forkhead box protein A1) is one of three members in the FoxA related family
(forkhead family of transcriptions factors). FoxA related family proteins are often termed …

Deciphering Ikbke Involvement in Hepatocellular Cancer HEPG2 Cells

E Xhafa - 2020 - search.proquest.com
Hepatocellular carcinoma (HCC) is the second leading cause of cancer related deaths
worldwide. The reasons behind high mortality in HCC patients include late diagnosis and …