Emerging data suggest that SSeCKS/Gravin/AKAP12 (“AKAP12”), originally identified as an
autoantigen in cases of myasthenia gravis, controls multiple biological processes through its …

Retinoic acid‐induced expression of the CD38 ectoenzyme receptor in HL‐60 human
myeloblastic leukemia cells is regulated by RARα and RXR, and enhanced or prevented cell …

Flotillin-1 and flotillin-2 are important regulators of signal transduction pathways such as
growth factor signaling. Flotillin expression is increased under pathological conditions such …

Manipulation of differentiation programs has therapeutic potential in a spectrum of human
cancers and neurodegenerative disorders. In this study, we integrated computational and …

Background SSeCKS is a major protein kinase C substrate with kinase scaffolding and
metastasis-suppressor activity whose expression is severely downregulated in Src-and Ras …

Retinoic acid (RA) is a fundamental regulator of cell cycle and cell differentiation. Using a
leukemic patient-derived in vitro model of a non-APL AML, we previously found that RA …

Classical population genetics shows that varying permutations of genes and risk factors
permit or disallow the effects of causative agents, depending on circumstance. For example …

The epithelium-specific ETS transcription factor-1 (ESE-1) is physiologically important in the
pathogenesis of various diseases. Recently, OCT4, a transcription factor involved in stem …

The inflammatory response is tightly regulated by several mediators that promote the
adhesive and migratory capacities of different cell types, including peripheral blood …

The P47phox cytosolic protein, also known as neutrophil cytosolic protein 1, is historically
regarded and significant as a central component of the NADPH oxidase complex …