Preoperative and postoperative systemic therapy for operable non–small-cell lung cancer

JE Chaft, Y Shyr, B Sepesi, PM Forde - Journal of Clinical Oncology, 2022 - ascopubs.org
Cisplatin-based adjuvant chemotherapy remains the standard of care for patients with
resected stage II or III non–small-cell lung cancer. However, biomarker-informed clinical …

Revisiting neoadjuvant therapy in non-small-cell lung cancer

SPL Saw, BH Ong, KLM Chua, A Takano… - The Lancet …, 2021 - thelancet.com
Despite the rapidly evolving treatment landscape in advanced non-small-cell lung cancer
(NSCLC), developments in neoadjuvant and adjuvant treatments have been nascent by …

PD-L1 expression and tumor mutation burden as pathological response biomarkers of neoadjuvant immunotherapy for early-stage non-small cell lung cancer: a …

H Deng, Y Zhao, X Cai, H Chen, B Cheng… - Critical reviews in …, 2022 - Elsevier
To date, there is no approved biomarker for predicting pathological response in neoadjuvant
programmed cell death (ligand) 1 (PD-(L) 1) blockades treated early-stage non-small cell …

[HTML][HTML] Neoadjuvant durvalumab for resectable non-small-cell lung cancer (NSCLC): results from a multicenter study (IFCT-1601 IONESCO)

M Wislez, J Mazieres, A Lavole, G Zalcman… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background The IONESCO (IFCT-1601) trial assessed the feasibility of neoadjuvant
durvalumab, for early-stage resectable non-small-cell lung cancer (NSCLC). Methods In a …

[HTML][HTML] Neoadjuvant immunotherapy or chemoimmunotherapy in non-small cell lung cancer: a systematic review and meta-analysis

J Jiang, Y Wang, Y Gao, H Sugimura… - Translational Lung …, 2022 - ncbi.nlm.nih.gov
Background In recent years, a series of clinical trials have explored the application of
neoadjuvant immunotherapy or chemoimmunotherapy in non-small cell lung cancer …

Treatment sequencing in resectable lung cancer: the good and the bad of adjuvant versus neoadjuvant therapy

M Provencio, V Calvo, A Romero, JD Spicer… - American Society of …, 2022 - ascopubs.org
The treatment scenario for patients with resectable non–small cell lung cancer has changed
dramatically with the incorporation of immunotherapy. The introduction of immunotherapy …

[HTML][HTML] Current surgical indications for non-small-cell lung cancer

N Deboever, KG Mitchell, HA Feldman, T Cascone… - Cancers, 2022 - mdpi.com
Simple Summary The management strategy for the treatment of non-small-cell lung cancer
(NSCLC) has been transformed by our improved understanding of the cancer biology and …

Tumor immunology and immunotherapy of non-small-cell lung cancer

T Cascone, J Fradette… - Cold Spring …, 2021 - perspectivesinmedicine.cshlp.org
Historically, non-small-cell lung cancer (NSCLC) has been regarded as a nonimmunogenic
tumor; however, recent studies have shown that NSCLCs are among the most responsive …

Neoadjuvant immunotherapy for non–small cell lung cancer: State of the art

J Kang, C Zhang, WZ Zhong - Cancer Communications, 2021 - Wiley Online Library
Lung cancer mortality has decreased over the past decade and can be partly attributed to
advances in targeted therapy and immunotherapy. Immune checkpoint inhibitors (ICIs) have …

[HTML][HTML] Role and impact of immune checkpoint inhibitors in neoadjuvant treatment for NSCLC

A Friedlaender, J Naidoo, GL Banna, G Metro… - Cancer treatment …, 2022 - Elsevier
In the last decade, immune-checkpoint inhibitors (ICIs) have become the backbone of
therapy in advanced, non-oncogene driven, non-small cell lung cancer (NSCLC). More …