Therapeutic drug repositioning with special emphasis on neurodegenerative diseases: Threats and issues

BB Kakoti, R Bezbaruah, N Ahmed - Frontiers in Pharmacology, 2022 - frontiersin.org
Drug repositioning or repurposing is the process of discovering leading-edge indications for
authorized or declined/abandoned molecules for use in different diseases. This approach …

Artificial intelligence in the management of neurodegenerative disorders

S Dhankhar, S Mujwar, N Garg… - CNS & Neurological …, 2024 - benthamdirect.com
Neurodegenerative disorders are characterized by a gradual but irreversible loss of
neurological function. The ability to detect and treat these conditions successfully is crucial …

[HTML][HTML] Evaluating the performance of drug-repurposing technologies

J Schuler, Z Falls, W Mangione, ML Hudson… - Drug discovery today, 2022 - Elsevier
Drug-repurposing technologies are growing in number and maturing. However,
comparisons to each other and to reality are hindered because of a lack of consensus with …

Impact of the renin-angiotensin system on the pathogeny and pharmacotherapeutics of neurodegenerative diseases

W Bild, A Vasincu, RN Rusu, DC Ababei, AB Stana… - Biomolecules, 2022 - mdpi.com
Brain neurodegenerative diseases (BND) are debilitating conditions that are especially
characteristic of a certain period of life and considered major threats to human health …

Protective role of anticancer drugs in neurodegenerative disorders: A drug repurposing approach

D Advani, R Gupta, R Tripathi, S Sharma… - Neurochemistry …, 2020 - Elsevier
The disease heterogeneity and little therapeutic progress in neurodegenerative diseases
justify the need for novel and effective drug discovery approaches. Drug repurposing is an …

Predicting target–ligand interactions with graph convolutional networks for interpretable pharmaceutical discovery

P Ruiz Puentes, L Rueda-Gensini, N Valderrama… - Scientific reports, 2022 - nature.com
Drug Discovery is an active research area that demands great investments and generates
low returns due to its inherent complexity and great costs. To identify potential therapeutic …

An early stage researcher's primer on systems medicine terminology

M Zanin, NAA Aitya, J Basilio, J Baumbach… - Network and systems …, 2021 - liebertpub.com
Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary
field that considers the human body as a system, composed of multiple parts and of complex …

Therapeutic Targeting of Antineoplastic Drugs in Alzheimer's Disease: Discovered in Repurposed Agents

M Dahiya, A Kumar, M Yadav, P Dhakla… - Drug Repurposing for …, 2023 - Springer
The heterogeneity and complexity of various pathological marker and few therapeutics
options make Alzheimer's disease (AD) a prime perpetrator to universal health that …

Vir2Drug: a drug repurposing framework based on protein similarities between pathogens

G Minadakis, M Tomazou, N Dietis… - Briefings in …, 2023 - academic.oup.com
We draw from the assumption that similarities between pathogens at both pathogen protein
and host protein level, may provide the appropriate framework to identify and rank candidate …

[PDF][PDF] A novel framework for drug synergy prediction using differential evolution based multinomial random forest

J Kaur, D Singh, M Kaur - International Journal of …, 2019 - pdfs.semanticscholar.org
An efficient prediction of drug synergy plays a significant role in the medical domain.
Examination of different drug-drug interaction can be achieved by considering the drug …