The potential relevance of long non-coding RNAs in colorectal cancer pathogenesis and treatment: a review focus on signaling pathways
Colorectal cancer (CRC) is one of the most frequent cancers in incidence and mortality.
Despite advances in cancer biology, molecular genetics, and targeted treatments, CRC …
Despite advances in cancer biology, molecular genetics, and targeted treatments, CRC …
[HTML][HTML] Mechanism of action and therapeutic implications of Nrf2/HO-1 in inflammatory bowel disease
L Yuan, Y Wang, N Li, X Yang, X Sun, H Tian, Y Zhang - Antioxidants, 2024 - mdpi.com
Oxidative stress (OS) is a key factor in the generation of various pathophysiological
conditions. Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a major transcriptional …
conditions. Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a major transcriptional …
Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: Novel insights on autophagy, apoptosis, and pyroptosis
R Abdelhady, S Saber… - Frontiers in …, 2023 - frontiersin.org
Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal area that
demonstrates a dramatically increasing incidence worldwide. This study provides novel …
demonstrates a dramatically increasing incidence worldwide. This study provides novel …
[HTML][HTML] Modulating the HSP90 control over NFκB/NLRP3/Caspase-1 axis is a new therapeutic target in the management of liver fibrosis: insights into the role of TAS …
Aberrant activation of the NLRP3 inflammasome is recognized to induce a chronic
inflammatory response in the liver, ultimately leading to hepatic fibrosis. HSP90 is suggested …
inflammatory response in the liver, ultimately leading to hepatic fibrosis. HSP90 is suggested …
[HTML][HTML] p-Hydroxy benzaldehyde, a phenolic compound from Nostoc commune, ameliorates DSS-induced colitis against oxidative stress via the Nrf2/HO-1/NQO-1/NF …
M Liu, G Guan, Y Wang, X Lu, X Duan, X Xu - Phytomedicine, 2024 - Elsevier
Background Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disease (IBD),
presents with limited current drug treatment options. Consequently, the search for safe and …
presents with limited current drug treatment options. Consequently, the search for safe and …
STA9090 as a potential therapeutic agent for liver fibrosis by modulating the HSP90/TβRII/proteasome interplay: novel insights from in vitro and in vivo investigations
Liver fibrosis is a progressive condition characterized by the build-up of fibrous tissue
resulting from long-term liver injury. Although there have been advancements in research …
resulting from long-term liver injury. Although there have been advancements in research …
Levetiracetam attenuates experimental ulcerative colitis through promoting Nrf2/HO-1 antioxidant and inhibiting NF-κB, proinflammatory cytokines and iNOS/NO …
K Amirshahrokhi, M Imani - International Immunopharmacology, 2023 - Elsevier
Ulcerative colitis (UC) is a serious inflammatory disease of the colon. The pathogenic
mechanisms of UC involve the activation of inflammatory and oxidative stress responses in …
mechanisms of UC involve the activation of inflammatory and oxidative stress responses in …
New Pyrazole-Clubbed Pyrimidine or Pyrazoline Hybrids as Anti-Methicillin-Resistant Staphylococcus aureus Agents: Design, Synthesis, In Vitro and In Vivo …
Two hybrid series of pyrazole-clubbed pyrimidines 5a–c and pyrazole-clubbed pyrazoline
compounds 6a, b and 7 were designed as attractive scaffolds to be investigated in vitro and …
compounds 6a, b and 7 were designed as attractive scaffolds to be investigated in vitro and …
Mitigation of Dextran-Sodium-Sulfate-Induced Colitis in Mice through Oral Administration of Microbiome-Derived Inosine and Its Underlying Mechanisms
W Guo, X Tang, Q Zhang, J Zhao, B Mao… - International Journal of …, 2023 - mdpi.com
Background: Colonic and serum inosine are significantly reduced in patients with
inflammatory bowel disease (IBD). Methods: This study aimed to explore whether …
inflammatory bowel disease (IBD). Methods: This study aimed to explore whether …
Itraconazole halts hepatocellular carcinoma progression by modulating sonic hedgehog signaling in rats: A novel therapeutic approach
Liver cancer stands as the fourth leading global cause of death, and its prognosis remains
grim due to the limited effectiveness of current medical interventions. Among the various …
grim due to the limited effectiveness of current medical interventions. Among the various …