The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic
variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP …

Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Aim To present an overview of exendin (9‐39) NH2 usage as a scientific tool in humans and
provide recommendations for dosage and infusion regimes. Methods We systematically …

Congenital hyperinsulinism (HI) is a genetic disorder in which pancreatic β-cell insulin
secretion is excessive and results in hypoglycemia that, without treatment, can cause brain …

Hypoglycemia is due to defects in the metabolic systems involved in the transition from the
fed to the fasting state or in the hormone control of these systems. In children, hypoglycemia …

OBJECTIVE The aim of this study was to assess whether exendin-(9-39) will increase fasting
and postprandial plasma glucose and decrease the incidence of hypoglycemia in children …

ABSTRACT G protein-coupled receptors (GPCRs) are a group of seven-transmembrane
receptor proteins that have proven to be successful drug targets. Antibodies are becoming …

Traditionally, bioanalytical laboratories do not report actual concentrations for samples with
results below the LOQ (BLQ) in pharmacokinetic studies. BLQ values are outside the method …

Incretin hormones play an important role in the regulation of glucose homeostasis through
their actions on the beta cells and other tissues. Glucagon-like peptide-1 (GLP-1) and …

The incretin system is an emerging new field that might provide valuable contributions to the
research of both the pathophysiology and therapeutic strategies in the treatment of diabetes …