Platelets play an essential role in maintaining homeostasis in the circulatory system after an
injury by forming a platelet thrombus, but they also occupy a central node in the …

Innate immunity is fundamental to our defense against microorganisms. Physiologically, the
intravascular innate immune system acts as a purging system that identifies and removes …

Patients with systemic lupus erythematosus (SLE) have a markedly increased risk to
develop cardiovascular disease, and traditional cardiovascular risk factors fail to account for …

Dysregulation of lymphocyte function, accumulation of autoantibodies and defective
clearance of circulating immune complexes and apoptotic cells are hallmarks of systemic …

The risk for thrombosis is significantly increased in systemic lupus erythematosus (SLE),
affecting both venous and arterial vessels. Activated platelets are known to participate in …

Background: Chondroitin sulfate (CS) is a glycosaminoglycan released by activated
platelets. Objective: Here we test the hypothesis that CS released by activated platelets can …

It has been reported that complement is activated on the surface of activated platelets,
despite the presence of multiple regulators of complement activation. To reinvestigate the …

The aim of this work was to examine a possible role of clot contraction/retraction in
thrombotic complications of systemic lupus erythematosus (SLE). Using a novel automated …

Among complications of systemic lupus erythematosus (SLE), thrombotic events are
relatively common and contribute significantly to the morbidity and mortality rates. An …

Systemic lupus erythematosus (SLE) is a potentially fatal multiorgan inflammatory disease
that primarily affects females. Due to the heterogeneity of clinical manifestations and lack of …