Role and therapeutic potential of melatonin in various type of cancers

S Gurunathan, M Qasim, MH Kang… - OncoTargets and …, 2021 - Taylor & Francis
Cancer is a large group of diseases and the second leading cause of death worldwide.
Lung, prostate, colorectal, stomach, and liver cancers are the most common types of cancer …

[HTML][HTML] Major roles of the circadian clock in cancer

C Huang, C Zhang, Y Cao, J Li, F Bi - Cancer Biology & Medicine, 2023 - ncbi.nlm.nih.gov
Circadian rhythms are natural rhythms that widely exist in all creatures, and regulate the
processes and physiological functions of various biochemical reactions. The circadian clock …

Circadian clock: a regulator of the immunity in cancer

Z Zhang, P Zeng, W Gao, Q Zhou, T Feng… - Cell Communication and …, 2021 - Springer
The circadian clock is an endogenous timekeeper system that controls and optimizes
biological processes, which are consistent with a master circadian clock and peripheral …

Role of melatonin in cancer: effect on clock genes

C Rodríguez-Santana, J Florido… - International Journal of …, 2023 - mdpi.com
The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that
generates rhythmic changes in many physiological processes. Increasing evidence links …

Antitumor effect of melatonin on breast cancer in experimental models: A systematic review

PIR Franco, JR do Carmo Neto, AC Milhomem… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Breast cancer is the most frequent malignant neoplasm in females. While conventional
treatments such as chemotherapy and radiotherapy are available, they are highly invasive …

The acidic tumor microenvironment enhances PD-L1 expression via activation of STAT3 in MDA-MB-231 breast cancer cells

YJ Kwon, EB Seo, AJ Jeong, SH Lee, KH Noh, S Lee… - BMC cancer, 2022 - Springer
Tumor acidosis, a common phenomenon in solid cancers such as breast cancer, is caused
by the abnormal metabolism of cancer cells. The low pH affects cells surrounding the …

Circadian clock genes modulate immune, cell cycle and apoptosis in the diagnosis and prognosis of pan-renal cell carcinoma

S Liu, Y Cheng, S Wang, H Liu - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Background: Pan-renal cell carcinoma (pan-RCC) is mainly divided into renal clear cell
carcinoma (KIRC), renal papillary cell carcinoma (KIRP), and chromophobe cell carcinoma …

Immune escape and metastasis mechanisms in melanoma: breaking down the dichotomy

CA Shirley, G Chhabra, D Amiri, H Chang… - Frontiers in …, 2024 - frontiersin.org
Melanoma is one of the most lethal neoplasms of the skin. Despite the revolutionary
introduction of immune checkpoint inhibitors, metastatic spread, and recurrence remain …

Redox and metabolic reprogramming in breast cancer and cancer‐associated adipose tissue

T Zakic, V Pekovic‐Vaughan, A Cvoro, A Korac… - FEBS …, 2024 - Wiley Online Library
Redox and metabolic processes are tightly coupled in both physiological and pathological
conditions. In cancer, their integration occurs at multiple levels and is characterized by …

Canonical WNT/β-catenin signaling upregulates aerobic glycolysis in diverse cancer types

M Rathee, SM Umar, AJR Dev, A Kashyap… - Molecular Biology …, 2024 - Springer
Despite many efforts, a comprehensive understanding and clarification of the intricate
connections within cancer cell metabolism remain elusive. This might pertain to intracellular …