Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …

The β‐amyloid precursor protein (APP) has been extensively studied for its role as the
precursor of the β‐amyloid protein (Aβ) of Alzheimer's disease. However, the normal …

Abstract Background Gene Expression database of Normal and Tumor tissues 2 (GENT2) is
an updated version of GENT, which has provided a user-friendly search platform for gene …

Although major advances in genomics have initiated an exciting new era of research, a lack
of information regarding cis-regulatory elements has limited the genetic improvement or …

One of the major properties of genes is their expression pattern. Notably, genes are often
classified as tissue specific or housekeeping. This property is of interest to molecular …

Human aging cannot be fully understood in terms of the constrained genetic setting.
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …

Although the genome is generally thought to be transcriptionally silent during mitosis,
technical limitations have prevented sensitive mapping of transcription during mitosis and …

Network “guilt by association”(GBA) is a proven approach for identifying novel disease
genes based on the observation that similar mutational phenotypes arise from functionally …

Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic
physiological changes in response to Arctic climates and a hyperlipid diet of primarily …

The development of molecularly targeted anticancer agents relies on large panels of tumour-
specific preclinical models closely recapitulating the molecular heterogeneity observed in …