Highlights•Mechanisms of nuclear size and shape regulation.•Cell cycle events that
influence nuclear morphology.•Nuclear morphology, chromatin organization, and gene …

It is well established that the nuclear envelope has many distinct direct connections to
chromatin that contribute to genome organization. The functional consequences of genome …

Tissue engineering strongly relies on the use of hydrogels as highly hydrated 3D matrices to
support the maturation of laden cells. However, because of the lack of microarchitecture and …

N 6-methyladenosine (m6A) is an abundant post-transcriptional modification that can impact
RNA fate via interactions with m6A-specific RNA binding proteins. Despite accumulating …

Cells perceive and relay external mechanical forces into the nucleus through the nuclear
envelope. Here we examined the effect of lowering substrate stiffness as a paradigm to …

Recent decades have seen increasing evidence for a role for both innate and adaptive
immunity in response to changes in and in the modulation of metabolic status. This new field …

Introduction The propagation of mechanochemical signals from the extracellular matrix to
the cell nucleus has emerged as a central feature in regulating cellular differentiation and de …

Choanoflagellates are the closest unicellular relatives of animals (Metazoa). These tiny
protists display complex life histories that include sessile as well as different pelagic stages …

Recent groundbreaking developments in Omics and bioinformatics have generated new
hope for overcoming the complexity and variability of (radio) biological systems while …

Actin stress fibers (SFs) generate intercellular tension and play important roles in cellular
mechanotransduction processes and the regulation of various cellular functions. We recently …