A bidirectional relationship exists between adipose tissue metabolism and iron regulation.
Total body fat, fat distribution and exercise influence iron status and components of the iron …

Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence
variants in the human genome to common traits and diseases. However, translating this …

Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed
a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and …

Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

For any given level of overall adiposity, individuals vary considerably in fat distribution. The
inherited basis of fat distribution in the general population is not fully understood. Here, we …

OBJECTIVE Fat content and volume of liver and pancreas are associated with risk of
diabetes in observational studies; whether these associations are causal is unknown. We …

To understand the causal role of adiposity and ectopic fat in type 2 diabetes and
cardiometabolic diseases, we aimed to identify two clusters of adiposity genetic variants …

Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease
and cardiometabolic diseases but often remains undiagnosed in clinical practice because of …

Background and aims Non-alcoholic fatty liver disease (NAFLD) is common worldwide and
has previously been reported to be associated with sleep traits. However, it is not clear …

Modern Western biomedical research and clinical practice are primarily focused on disease.
This disease-centric approach has yielded an impressive amount of knowledge around what …