The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by
ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting …

The concept of a purinergic signaling system, using purine nucleotides and nucleosides as
extracellular messengers, was first proposed over 30 years ago. After a brief introduction …

Extracellular nucleotides have been recognized as important mediators of activation,
triggering multiple responses via plasma membrane receptors known as P2 receptors. P2 …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

The role of ATP as an extracellular signalling molecule is now well established and
evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

This new edition of Animal Models in Cardiovascular Research describes historical and
recent advances in our understanding of the cardiovascular system from studies conducted …

Activation of a cardiac myocyte P2X4 receptor protects against heart failure. 5′-
Phosphonate and 5′-phosphate analogues of AMP containing a (N)-methanocarba …

Cardiomyocytes (CMs) are nonregenerative. Self-renewable pluripotent human embryonic
stem cells (hESCs) can differentiate into CMs for cell-based therapies. We recently reported …

P2X4 receptors are ATP-gated cation channels that are widely expressed in the nervous
system. To identify P2X4 receptor-expressing cells, we generated BAC transgenic mice …