In humans and other adult mammals, axon regeneration is difficult in axotomized neurons.
Therefore, spinal cord injury (SCI) is a devastating event that can lead to permanent loss of …

Spinal cord injury (SCI) is a medical condition affecting~ 2.5–4 million people worldwide.
The conventional therapy for SCI fails to restore the lost spinal cord functions; thus, novel …

Gastrointestinal (GI) complications, including motility disorders, metabolic deficiencies, and
changes in gut microbiota following spinal cord injury (SCI), are associated with poor …

Objective Therapeutic translation is challenging in spinal cord injury (SCI) and large animal
models with high clinical relevance may accelerate therapeutic development. Pigs have …

Study design prospective case series of Yucatan miniature pig spinal cord contusion injury
model with comparison to human cases of spinal cord injury (SCI). Objectives to describe …

Spinal cord injury (SCI) is a severe neurological condition that involves a lengthy
pathological process. This process leads to the upregulation of chondroitin sulfate …

Objectives To explore filtered diffusion‐weighted imaging (fDWI), in comparison with
conventional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI), as a …

Introduction Spinal cord injury (SCI) is a devastating neurological disorder with an enormous
impact on individual's life and society. A reliable and reproducible animal model of SCI is …

Background Preclinical models are essential for identifying changes occurring after
neurologic injury and assessing therapeutic interventions. Yucatan miniature pigs (minipigs) …

Brain-derived neurotrophic factor (BDNF) plays a vital role in supporting neuronal survival,
differentiation, and promoting synaptogenesis, thereby facilitating synaptic plasticity in the …