Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

In eukaryotes, chromatin and DNA replication are intimately linked, whereby chromatin
impacts DNA replication control while genome duplication involves recovery of chromatin …

As with all new fields of discovery, work on the biological role of G-quadruplexes (GQs) has
produced a number of results that at first glance are quite baffling, sometimes because they …

DNA replication ensures the precise transmission of genetic information from parent to
daughter cells. In eukaryotes, this process involves the replication of every base pair within a …

In 2023, the brilliant chromatin biologist C. David Allis passed away leaving a large void in
the scientific community and broken hearts in his family and friends. With this review, we …

Background: We recently identified tandem repeats of GGN triplets as a sequence motif
strongly enriched in the DNA replication origins (ORIs) of the Arabidopsis thaliana genome …

Simple Summary Genome duplication and the faithful segregation of chromosomes to
daughter cells are crucial for the maintenance of genome stability. Replication initiators play …

The structure of eukaryotic origins is a long-standing question in the DNA replication field,
and the universal features that define the genomic regions acting as replication starting sites …

DNA replication initiates at tens of thousands of sites on the human genome during each S
phase. However, no consensus DNA sequence has been found that specifies the locations …

G-quadruplex DNA structures (G4s) form within single-stranded DNA in nucleosome-free
chromatin. As G4s modulate gene expression and genomic stability, genome-wide mapping …