The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the
inner leaflet of the plasma membrane in neural tissues. PS is synthesized from …

Ras is a prototypical small G-protein and a central regulator of growth, proliferation and
differentiation processes in virtually every nucleated cell. As such, Ras becomes engaged …

Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in
numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis …

Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to
biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are …

To function in fusion and signaling, Rab GTPases need to be converted into their active GTP
form. We previously identified the conserved Mon1–Ccz1 complex as the guanine …

Ras-specific GTPase-activating proteins (RasGAPs) down-regulate the biological activity of
Ras proteins by accelerating their intrinsic rate of GTP hydrolysis, basically by a transition …

Abstract The Mon1–Ccz1 complex (MC1) is the guanine nucleotide exchange factor (GEF)
for the Rab GTPase Ypt7/Rab7 and is required for endosomal maturation and fusion at the …

Inactivation of the small guanosine triphosphate–binding protein Ras during receptor signal
transduction is mediated by Ras guanosine triphosphatase (GTPase)–activating proteins …

Within eukaryotic cells, biochemical reactions need to be organized on the surface of
membrane compartments that use distinct lipid constituents to dynamically modulate the …