The increasing global prevalence of type 2 diabetes mellitus (T2DM) and chronic kidney
disease (CKD) has prompted research efforts to tackle the growing epidemic of diabetic …

Diabetes and cancer are among the most frequent and complex diseases. Epidemiological
evidence showed that the patients suffering from diabetes are significantly at higher risk for a …

INTRODUCTION Antiphospholipid antibodies (aPLs) transiently appear in infectious
diseases but can persist in primary antiphospholipid syndrome (APS) or in association with …

A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific
therapies. Here we show that glucose-mediated changes in gene expression largely persist …

Rationale: While thrombin is the key protease in thrombus formation, other coagulation
proteases, such as fXa (factor Xa) or aPC (activated protein C), independently modulate …

Tissue factor (TF), which is a member of the cytokine receptor family, promotes coagulation
and coagulation-dependent inflammation. TF also exerts protective effects through unknown …

Dysfunction of mesangial cells plays a major role in the pathogenesis of diabetic kidney
disease (DKD), the leading cause of kidney failure. However, the underlying molecular …

Cell biology of activated protein C : Current Opinion in Hematology Cell biology of activated
protein C : Current Opinion in Hematology Log in or Register Subscribe to journalSubscribe …

Aims: The pathogenesis of diabetic cardiomyopathy (DCM) is complex and the detailed
mechanism remains unclear. Coagulation protease activated Protein C (aPC) has been …

Impaired activated protein C (aPC) generation is associated with atherosclerosis and
diabetes mellitus. Diabetes-associated atherosclerosis is characterized by the …