Ubiquitination is a key post-translational modification of proteins, affecting the regulation of
multiple cellular processes. Cells are equipped with over 600 ubiquitin orchestrators, called …

During S phase, the cooperation between the macromolecular complexes regulating DNA
synthesis, epigenetic information maintenance and DNA repair is advantageous for cells, as …

SMNDC1 is a Tudor domain protein that recognizes di-methylated arginines and controls
gene expression as an essential splicing factor. Here, we study the specific contributions of …

Fragment-based drug discovery (FBDD) has successfully led to approved therapeutics for
challenging and “undruggable” targets. In the context of FBDD, we introduce a novel …

Introduction Berberine (BBR), as one of the outstanding representatives of isoquinoline
alkaloids, has been used as an antibacterial drug for a long time in China since ancient …

Histone methylation reader domains are protein modules that recognize specific histone
methylation marks, such as methylated or unmethylated lysine or arginine residues on …

Fragment‐based drug discovery (FBDD) is a method of identifying small molecule hits that
can be elaborated rationally through fragment growing, merging and linking, to afford high …

DNA double-strand breaks (DSBs) are hazardous to genome integrity and can promote
mutations and disease if not handled correctly. Cells respond to these dangers by engaging …

KRAS is a frequent driver in lung cancer. To identify KRAS-specific vulnerabilities in lung
cancer, we performed RNAi screens in primary spheroids derived from a Kras mutant mouse …

DNA methylation is involved in numerous biological processes and is deregulated in human
diseases. The modulation of the activity of the enzymes and proteins in charge of DNA …