Modeling membrane curvature generation due to membrane–protein interactions

H Alimohamadi, P Rangamani - Biomolecules, 2018 - mdpi.com
To alter and adjust the shape of the plasma membrane, cells harness various mechanisms
of curvature generation. Many of these curvature generation mechanisms rely on the …

A review of mechanics-based mesoscopic membrane remodeling methods: capturing both the physics and the chemical diversity

G Kumar, SC Duggisetty, A Srivastava - The Journal of Membrane Biology, 2022 - Springer
Specialized classes of proteins, working together in a tightly orchestrated manner, induce
and maintain highly curved cellular and organelles membrane morphology. Due to the …

Biophysics of membrane curvature remodeling at molecular and mesoscopic lengthscales

N Ramakrishnan, RP Bradley… - Journal of Physics …, 2018 - iopscience.iop.org
At the micron scale, where cell organelles display an amazing complexity in their shape and
organization, the physical properties of a biological membrane can be better-understood …

Interactions between model inclusions on closed lipid bilayer membranes

T Idema, DJ Kraft - Current Opinion in Colloid & Interface Science, 2019 - Elsevier
Protein inclusions in the membranes of living cells interact via the deformations they impose
on that membrane. Such membrane-mediated interactions lead to sorting and self-assembly …

Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion

J Zhu, ZA McDargh, F Li… - Proceedings of the …, 2022 - National Acad Sciences
Synchronous release at neuronal synapses is accomplished by a machinery that senses
calcium influx and fuses the synaptic vesicle and plasma membranes to release …

Transition from curvature sensing to generation in a vesicle driven by protein binding strength and membrane tension

TVS Krishnan, SL Das, PBS Kumar - Soft Matter, 2019 - pubs.rsc.org
The ability of proteins to sense and/or generate membrane curvature is crucial for many
biological processes inside the cell. We introduce a model for the binding and unbinding of …

Exploring large-scale phenomena in composite membranes through an efficient implicit-solvent model4

M Laradji, PBS Kumar… - Journal of Physics D …, 2016 - iopscience.iop.org
Several microscopic and mesoscale models have been introduced in the past to investigate
various phenomena in lipid membranes. Most of these models account for the solvent …

[HTML][HTML] The mesoscopic membrane with proteins (MesM-P) model

A Davtyan, M Simunovic, GA Voth - The Journal of Chemical Physics, 2017 - pubs.aip.org
We present the Mesoscopic Membrane with Proteins (MesM-P) model, an extension of a
previously developed elastic membrane model for mesoscale simulations of lipid …

Membrane remodeling due to a mixture of multiple types of curvature proteins

G Kumar, A Srivastava - Journal of Chemical Theory and …, 2022 - ACS Publications
We present an extension of the Monte Carlo based mesoscopic membrane model, where
the membrane is represented as a dynamically triangulated surface and the proteins are …

Nonaxisymmetric shapes of biological membranes from locally induced curvature

YAD Omar, A Sahu, RA Sauer, KK Mandadapu - Biophysical journal, 2020 - cell.com
In various biological processes such as endocytosis and caveolae formation, the cell
membrane is locally deformed into curved morphologies. Previous models to study …