Artemisinins in combating viral infections like SARS-CoV-2, inflammation and cancers and options to meet increased global demand

K Farmanpour-Kalalagh… - Frontiers in Plant …, 2022 - frontiersin.org
Artemisinin is a natural bioactive sesquiterpene lactone containing an unusual
endoperoxide 1, 2, 4-trioxane ring. It is derived from the herbal medicinal plant Artemisia …

Inverse α-Effect as the Ariadne's Thread on the Way to Tricyclic Aminoperoxides: Avoiding Thermodynamic Traps in the Labyrinth of Possibilities

IA Yaremenko, YY Belyakova, PS Radulov… - Journal of the …, 2022 - ACS Publications
Stable tricyclic aminoperoxides can be selectively assembled via a catalyst-free three-
component condensation of β, δ′-triketones, H2O2, and an NH-group source such as …

Marriage of peroxides and nitrogen heterocycles: selective three-component assembly, peroxide-preserving rearrangement, and stereoelectronic source of unusual …

IA Yaremenko, YY Belyakova, PS Radulov… - Journal of the …, 2021 - ACS Publications
Stable bridged azaozonides can be selectively assembled via a catalyst-free three-
component condensation of 1, 5-diketones, hydrogen peroxide, and an NH-group source …

Cascade assembly of bridged N-substituted azaozonides: the counterintuitive role of nitrogen source nucleophilicity

IA Yaremenko, YY Belyakova, PS Radulov… - Organic …, 2022 - ACS Publications
Counterintuitively, the low basicity of the NH2 group in hydrazides makes them preferred
nucleophiles for the synthesis of the N-substituted azaozonides in acid-catalyzed three …

Two-Component versus Three-Component Condensations in the Race between Hydrazide, Triketone, and Hydrogen Peroxide-How do All Six Reactive Centers …

IA Yaremenko, YY Belyakova, PS Radulov… - The Journal of …, 2023 - ACS Publications
Relief of stereoelectronic frustration drives the acid-catalyzed three-component
condensation of β, δ′-triketones with hydrazides and H2O2 to the direction where both …

Nitric Oxide Radical-Based Nanoparticles as Magnetic Resonance Imaging Probes for Ascorbic Acid Quantification

N Iizuka, Y Akizuki, T Umeno, N Suzuki… - ACS Applied Nano …, 2024 - ACS Publications
Ascorbic acid (AsA) is intravenously administered as a drug for disease therapy, fatigue
recovery, antiaging, and cancer therapies. However, the traditionally quantitative AsA …

Push–Pull Bisnaphthyridylamine Supramolecular Nanoparticles: Polarity‐Induced Aggregation and Crystallization‐Induced Emission Enhancement and Fluorescence …

R Hagihara, T Umeno, S Ueki… - … A European Journal, 2021 - Wiley Online Library
Emissive push–pull‐type bisnaphthyridylamine derivatives (BNA‐X: X= Me, Et, Bzl, Ph,
BuBr, and BuTEMPO) aggregate in aqueous methanol. Furthermore, a two‐step emission …

Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α

T Shimizu, N Takahashi, VJ Huber, Y Asawa… - Bioorganic & Medicinal …, 2021 - Elsevier
Inspired by the privileged molecular skeletons of 14-and 15-membered antibiotics, we
adopted a relatively unexplored synthetic approach that exploits alkaloidal macrocyclic …

Synthesis and Structural Diversification of Artemisinins towards the Generation of Potent Anti-malarial Agents

H Oguri - Chemistry Letters, 2021 - academic.oup.com
Artemisinin and its semi-synthetic derivatives have been the cornerstone of malaria
chemotherapy. Their life-saving therapeutic effects and characteristic structure bearing a …

Synthesis of cyclic aza-peroxides (microreview)

YY Belyakova, PS Radulov - Chemistry of Heterocyclic Compounds, 2021 - Springer
Synthesis of cyclic aza-peroxides (microreview) | SpringerLink Skip to main content
Advertisement SpringerLink Log in Menu Find a journal Publish with us Search Cart 1.Home …