[HTML][HTML] Timing of lifespan influences on brain and cognition

KB Walhovd, M Lövden, AM Fjell - Trends in cognitive sciences, 2023 - cell.com
Modifiable risk and protective factors for boosting brain and cognitive development and
preventing neurodegeneration and cognitive decline are embraced in neuroimaging …

Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification

Å Johansson, OA Andreassen, S Brunak… - Journal of internal …, 2023 - Wiley Online Library
Complex diseases are caused by a combination of genetic, lifestyle, and environmental
factors and comprise common noncommunicable diseases, including allergies …

2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of …

G Mancia, R Kreutz, M Brunström, M Burnier… - Journal of …, 2023 - journals.lww.com
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

[HTML][HTML] A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease

AP Patel, M Wang, Y Ruan, S Koyama, SL Clarke… - Nature Medicine, 2023 - nature.com
Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …

Molecular mechanisms of vascular health: insights from vascular aging and calcification

NR Sutton, R Malhotra, C St. Hilaire… - … , and vascular biology, 2023 - Am Heart Assoc
Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …

Coronary artery calcium score and polygenic risk score for the prediction of coronary heart disease events

SS Khan, WS Post, X Guo, J Tan, F Zhu, D Bos… - Jama, 2023 - jamanetwork.com
Importance Coronary artery calcium score and polygenic risk score have each separately
been proposed as novel markers to identify risk of coronary heart disease (CHD), but no …

[HTML][HTML] Frequent questions and responses on the 2022 lipoprotein (a) consensus statement of the European Atherosclerosis Society

F Kronenberg, S Mora, ESG Stroes, BA Ference… - Atherosclerosis, 2023 - Elsevier
Abstract In 2022, the European Atherosclerosis Society (EAS) published a new consensus
statement on lipoprotein (a)[Lp (a)], summarizing current knowledge about its causal …

Prime editing using CRISPR-Cas12a and circular RNAs in human cells

R Liang, Z He, KT Zhao, H Zhu, J Hu, G Liu… - Nature …, 2024 - nature.com
Genome editing with prime editors based on CRISPR-Cas9 is limited by the large size of the
system and the requirement for a G/C-rich protospacer-adjacent motif (PAM) sequence …

Wrestling with social and behavioral genomics: risks, potential benefits, and ethical responsibility

MN Meyer, PS Appelbaum, DJ Benjamin… - Hastings Center …, 2023 - Wiley Online Library
In this consensus report by a diverse group of academics who conduct and/or are concerned
about social and behavioral genomics (SBG) research, the authors recount the often‐ugly …

[PDF][PDF] 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of …

M Brunström, M Burnier… - Journal of …, 2023 - docred-strapi-cms-prod.s3.sa-east-1 …
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …