Review and perspective on bioinformatics tools using machine learning and deep learning for predicting antiviral peptides

N Lefin, L Herrera-Belén, JG Farias, JF Beltrán - Molecular Diversity, 2023 - Springer
Viruses constitute a constant threat to global health and have caused millions of human and
animal deaths throughout human history. Despite advances in the discovery of antiviral …

New Perspectives about Drug Candidates Targeting HTLV-1 and Related Diseases

MCM Silva, RSB Pereira, ACA Araujo, EGS Filho… - Pharmaceuticals, 2023 - mdpi.com
Among the human T-lymphotropic virus (HTLV) types, HTLV-1 is the most prevalent, and it
has been linked to a spectrum of diseases, including HAM/TSP, ATLL, and hyperinfection …

Kallistatin as an inhibitory protein against colorectal cancer cells through binding to LRP6

B Shahbazi, L Mafakher, SS Arab… - Journal of …, 2024 - Taylor & Francis
Kallistatin (KL) is a member of the serine proteinase inhibitor (serpin) family regulating
oxidative stress, vascular relaxation, inflammation, angiogenesis, cell proliferation, and …

Screening of potent inhibitor from Aquilaria malaccensis Lam. against arachidonic inflammatory enzymes: an insight from molecular docking, ADMET, molecular …

P Sarmah, P Konwar, J Saikia, T Borah… - Journal of …, 2023 - Taylor & Francis
The three primary enzymes COX (cyclooxygenase), LOX (lipoxygenase) and CYT-P450
(cytochrome P450), which are part of the arachidonic inflammatory pathway, play crucial role …

Computational screening of FDA-approved drugs to identify potential aromatase receptor inhibitors for polycystic ovary syndrome

F Koohnavard, K Ahmadi, E Eftekhar… - Journal of …, 2023 - Taylor & Francis
Polycystic ovary syndrome (PCOS) is the most common cause of infertility without ovulation.
Aromatase inhibitors were first proposed as new ovulation-inducing drugs in anovulatory …

Computational screening of FDA-approved drugs to identify potential TgDHFR, TgPRS, and TgCDPK1 proteins inhibitors against Toxoplasma gondii

Z Gharibi, B Shahbazi, H Gouklani, H Nassira… - Scientific Reports, 2023 - nature.com
Toxoplasma gondii (T. gondii) is one of the most successful parasites in the world, because
about a third of the world's population is seropositive for toxoplasmosis. Treatment regimens …

Combating HTLV-1 infections with Taxus baccata phytoconstituents: Molecular Mechanisms Potential anti-ATLL Agents

A Baghban, SAR Rezaee, M Tafaghodi… - Pharmacological …, 2024 - Elsevier
Taxus baccata is recognized as a traditional herb with antiviral and anticancer properties,
making it a valuable candidate for anti-proliferative and antiviral agents, particularly in the …

[PDF][PDF] MAESOPSIN AS MAO-A, MAO-BAND ACHE INHIBITORS AND INVESTIGATION OF ANTI-LUNG AND ANTI-COLON CANCER EFFECTS WITH MOLECULAR …

WEI MENG, Y CAO, HUI CHENG, NA XU - ijcce.ac.ir
Creating novel enzyme inhibitors and anti-cancer medications has been a major objective of
medicinal chemistry in recent years. The study also examined the capacity of Maesopsin to …