Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …

Prospective observational studies support the use of long-chain omega-3 polyunsaturated
fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; …

Background Despite early interest in the health effects of polyunsaturated fatty acids (PUFA),
there is still substantial controversy and uncertainty on the evidence linking PUFA to …

Background Abdominal obesity has been shown to be a superior measure over overall
obesity for detecting cardiovascular risk. Objective We conducted this study to compare the …

Cardiovascular outcome trials on omega-3 fatty acids have generated contradictory results
but indicate a dose-dependent beneficial effect of eicosapentaenoic acid (EPA). Beneficial …

Mendelian randomization can be used as a tool to improve causal inference in
observational studies assessing the role of nutritional factors and metabolites in health and …

Fatty Acid Desaturase-1 (FADS1) or delta 5 desaturase (D5D) is a rate-limiting enzyme
involved in the biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), ie …

Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …

Background Arachidonic acid (AA), a major long-chain n-6 polyunsaturated fatty acid in
animal foods, has been linked to inflammation, coagulation, and testosterone, which might …

Objectives The role of plasma phospholipid arachidonic acid (AA) in the development of non-
alcoholic fatty liver disease (NALFD), cirrhosis, and liver cancer remains unclear. This study …