Role of the immune system in the development of the central nervous system

K Morimoto, K Nakajima - Frontiers in Neuroscience, 2019 - frontiersin.org
The central nervous system (CNS) and the immune system are both intricate and highly
organized systems that regulate the entire body, with both sharing certain common features …

Specification of synaptic connectivity by cell surface interactions

J De Wit, A Ghosh - Nature Reviews Neuroscience, 2016 - nature.com
The molecular diversification of cell surface molecules has long been postulated to impart
specific surface identities on neuronal cell types. The existence of unique cell surface …

Cells of the adult human heart

M Litviňuková, C Talavera-López, H Maatz, D Reichart… - Nature, 2020 - nature.com
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and therapeutic strategies require a deeper understanding of the …

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies

D Reichart, EL Lindberg, H Maatz, AMA Miranda… - Science, 2022 - science.org
Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic
cardiomyopathy (ACM) convey high risks for the development of heart failure through …

Quantitative temporal viromics: an approach to investigate host-pathogen interaction

MP Weekes, P Tomasec, EL Huttlin, CA Fielding… - Cell, 2014 - cell.com
A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

Hsa_circ_0001666 suppresses the progression of colorectal cancer through the miR‐576‐5p/PCDH10 axis

J Zhou, L Wang, Q Sun, R Chen… - Clinical and …, 2021 - Wiley Online Library
Abstract Background Though circular RNAs, new non‐coding RNA classes have
demonstrated that they have an essential role in the initiation as well as development of …

Thinking outside the cell: how cadherins drive adhesion

J Brasch, OJ Harrison, B Honig, L Shapiro - Trends in cell biology, 2012 - cell.com
Cadherins are a superfamily of cell surface glycoproteins whose ectodomains contain
multiple repeats of β-sandwich extracellular cadherin (EC) domains that adopt a similar fold …

Protocadherins at the crossroad of signaling pathways

A Pancho, T Aerts, MD Mitsogiannis… - Frontiers in Molecular …, 2020 - frontiersin.org
Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …

[HTML][HTML] Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

NP Tsai, JR Wilkerson, W Guo, MA Maksimova… - Cell, 2012 - cell.com
The activity-dependent transcription factor myocyte enhancer factor 2 (MEF2) induces
excitatory synapse elimination in mouse neurons, which requires fragile X mental …

The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells

D Choi, L Montermini, DK Kim, B Meehan… - Molecular & Cellular …, 2018 - ASBMB
Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary
brain tumors, driven by a complex repertoire of oncogenic alterations, including the …