DNA diagnostics by capillary electrophoresis

K Kleparnik, P Bocek - Chemical reviews, 2007 - ACS Publications
Early molecular methods in clinical genetic diagnostics were frequently regarded as
unambiguous and definitive. The power of modern molecular biology was seen as sufficient …

Nanomaterials and chip‐based nanostructures for capillary electrophoretic separations of DNA

YW Lin, MF Huang, HT Chang - Electrophoresis, 2005 - Wiley Online Library
Capillary electrophoresis (CE) and microchip capillary electrophoresis (MCE) using polymer
solutions are two of the most powerful techniques for the analysis of DNA. Problems, such as …

Rapid identification of HBB gene mutations by high-resolution melting analysis

HC Shih, TK Er, TJ Chang, YS Chang, TC Liu… - Clinical …, 2009 - Elsevier
OBJECTIVE: This study was undertaken to identify HBB gene mutation. DESIGN AND
METHODS: Herein we evaluated high-resolution melting analysis in the identification of …

Determination of glycine, glutamine, glutamate, and γ-aminobutyric acid in cerebrospinal fluids by capillary electrophoresis with light-emitting diode-induced …

MJ Lu, TC Chiu, PL Chang, HT Ho, HT Chang - Analytica chimica acta, 2005 - Elsevier
In this article, we present a simple and cost-effective method for the determination of amino
acids in cerebrospinal fluids (CSF) by using capillary electrophoresis-light-emitting diode …

Determination of the heterogeneity of DNA methylation by combined bisulfite restriction analysis and capillary electrophoresis with laser-induced fluorescence

HC Chen, YS Chang, SJ Chen, PL Chang - Journal of chromatography A, 2012 - Elsevier
The methylation of the promoter region of DNA is an important regulatory mechanism for the
downstream gene expression, and the extent of methylation has been linked to cancer …

Fluorescence spectroscopy as a novel technique for premarital screening of sickle cell disorders

S Devanesan, MS AlSalhi, V Masilamani… - Photodiagnosis and …, 2021 - Elsevier
Spectral diagnostic screening for sickle cell disease was carried out on volunteer blood
samples (N= 100). The samples were subjected to different diagnostic methods including …

Improved capillary electrophoresis through the use of smart materials

M Zarei - Handbook of Smart Materials in Analytical Chemistry, 2019 - Wiley Online Library
Capillary electrophoresis (CE) is a well‐established separation technique, which provides
advantages of high speed, excellent resolving power, high separation efficiency, small …

Microfluidic Chip-Capillary Electrophoresis: Expanding the Scope of Application for On-Site Analysis of Difficult Samples

YS Fung - Microfluidic Chip-Capillary Electrophoresis Devices, 2015 - api.taylorfrancis.com
Due to the rising demand for on-site analysis to deliver timely results in the diagnosis of
infective agents and treatment of patients under critical conditions, assay of drugs and …

Rapid screening of the heterogeneity of DNA methylation by single‐strand conformation polymorphism and CE‐LIF in the presence of electro‐osmotic flow

MH Yu, YC Huang, PL Chang - Electrophoresis, 2014 - Wiley Online Library
DNA methylation is a complex event in epigenetic studies because of both the large C p G
islands present upstream of the promoter region and the different distribution of DNA …

Low viscous separation media for genomics and proteomics analysis on microchip electrophoresis system

M Jabasini, Y Murakami, N Kaji, M Tokeshi… - Biological and …, 2006 - jstage.jst.go.jp
Microchip electrophoresis has widely grown during the past few years, and it has showed a
significant result as a strong separation tool for genomic as well as proteomic researches. To …