Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Increasing evidence underlines that prototypical inflammatory cytokines (IL-1β, TNF-α and IL-
6) either synthesized in the central (CNS) or peripheral nervous system (PNS) by resident …

Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …

Neuropathic pain syndromes—pain after a lesion or disease of the peripheral or central
nervous system—are clinically characterized by spontaneous and evoked types of pain …

Relentless, repetitive itching and scratching is a debilitating feature of many chronic
inflammatory skin disorders such as atopic dermatitis. While well known clinically, this itch …

The spinal cord is the first relay site in the transmission of nociceptive information from the
periphery to the brain. Sensory signals are transmitted from the periphery by primary afferent …

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …

Pain is one of the classical signs of the inflammatory process in which sensitization of the
nociceptors is the common denominator. This sensitization causes hyperalgesia or allodynia …