Anal cancer is a rare cancer that accounts for about 2% of all gastrointestinal tract
malignancies. Among anal cancer, squamous cell cancer is the most common malignancy …

Background Anal canal squamous cell carcinoma (SCC) is a relatively uncommon
neoplasia, and it is mostly a local‐regional cancer, of low metastatic potential (only 15%) …

Background: The number of anal cancer diagnoses has been rising steadily, so that the
incidence has doubled in the past 20 years. Almost all anal cancers are induced by …

Purpose Squamous cell carcinoma of the anus (SCCA) suffers a constant increase each
year in the last decades. Recent studies suggested the possibility of local excision (LE) as …

Background and purpose This systematic review summarised and critically appraised
evidence on the efficacy and safety of interventions for anal cancer to support the panel of …

Aim There is a paucity of data on outcomes from local excision (LE) of early anal squamous
cell carcinomas (ASCCs). This study aimed to assess survival outcomes according to tumour …

Introduction Chemoradiation therapy (CRT) is the standard treatment for anal squamous cell
carcinoma (ASCC) but can have significant treatment related toxicities. Recent studies have …

Simple Summary Management of early-stage squamous cell carcinoma of the anus (SCCA)
remains controversial. The current standard of care treatment of chemotherapy combined …

Background The standard treatment for anal squamous cell carcinoma is chemoradiation
therapy (CRT), but there is a possibility of over-treatment for early-stage disease. cTisN0 and …

Background Guidelines recommend elective irradiation of the external iliac and upper pelvic
lymph nodes (LNs) regardless of clinical stage, but the supporting evidence for this …