[HTML][HTML] MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases
H Zhou, Y He, W Xiong, S Jing, X Duan, Z Huang… - Bioactive materials, 2023 - Elsevier
Mesenchymal stem cells (MSCs) are promising seed cells for neural regeneration therapy
owing to their plasticity and accessibility. They possess several inherent characteristics …
owing to their plasticity and accessibility. They possess several inherent characteristics …
Innovative nonviral gene delivery strategies for engineering human mesenchymal stem cell phenotypes toward clinical applications
A Hamann, AK Pannier - Current opinion in biotechnology, 2022 - Elsevier
Highlights•hMSCs have been registered in almost 1,000 clinical trials, but no FDA
approvals.•Nonviral gene delivery could enhance hMSCs, but is inefficient.•hMSC …
approvals.•Nonviral gene delivery could enhance hMSCs, but is inefficient.•hMSC …
The Effect of miR-140-5p with HDAC4 towards growth and differentiation signaling of chondrocytes in thiram-induced tibial dyschondroplasia
W Yao, MFA Kulyar, Y Ding, H Du, J Hong… - International Journal of …, 2023 - mdpi.com
There is evidence to suggest that microRNA-140-5p (miR-140), which acts as a suppressor,
is often elevated and has a role in various malignancies. Nevertheless, neither the function …
is often elevated and has a role in various malignancies. Nevertheless, neither the function …
Systematic comparison of nonviral gene delivery strategies for efficient co-expression of two transgenes in human mesenchymal stem cells
T Kozisek, L Samuelson, A Hamann… - Journal of Biological …, 2023 - Springer
Background Human mesenchymal stem cells (hMSCs) are being researched for cell-based
therapies due to a host of unique properties, however, genetic modification of hMSCs …
therapies due to a host of unique properties, however, genetic modification of hMSCs …
Propionate alleviates itch in murine models of atopic dermatitis by modulating sensory TRP channels of dorsal root ganglion
Y Xu, Z Qiu, C Gu, S Yu, S Wang, C Li, X Yao, W Li - Allergy, 2024 - Wiley Online Library
Background Itch is the most common symptom of atopic dermatitis (AD) and significantly
decreases the quality of life. Skin microbiome is involved in AD pathogenesis, whereas its …
decreases the quality of life. Skin microbiome is involved in AD pathogenesis, whereas its …
Designing molecules: directing stem cell differentiation
K Thanaskody, FN Natashah, F Nordin… - … in Bioengineering and …, 2024 - frontiersin.org
Stem cells have been widely applied in regenerative and therapeutic medicine for their
unique regenerative properties. Although much research has shown their potential, it …
unique regenerative properties. Although much research has shown their potential, it …
Effect of photobiomodulation therapy on the morphology, intracellular calcium concentration, free radical generation, apoptosis and necrosis of human mesenchymal …
K Pasternak-Mnich, A Szwed-Georgiou… - Lasers in Medical …, 2024 - Springer
The aim of the study was to investigate the impact of multiwave locked system (MLS M1)
emitting synchronized laser radiation at 2 wavelength simultaneous (λ= 808 nm, λ= 905 nm) …
emitting synchronized laser radiation at 2 wavelength simultaneous (λ= 808 nm, λ= 905 nm) …
局部载药系统促进骨折愈合的研究与应用
贾源源， 段棉棉， 唐正龙 - 中国组织工程研究, 2023 - cjter.com
摘要背景: 由于骨骼独特的解剖生理特征, 成骨药物严格的剂量依赖性, 使骨折区域给药系统仍然
受到限制. 近年来, 随着组织工程技术的发展, 载药体系的精细化与可控化 …
受到限制. 近年来, 随着组织工程技术的发展, 载药体系的精细化与可控化 …
Human Mesenchymal Stem Cells Modified with the NS5A Gene of Hepatitis C Virus Induce a Cellular Immune Response Exceeding the Response to DNA …
OV Masalova, EI Lesnova, VA Kalsin, RR Klimova… - Biology, 2023 - mdpi.com
Simple Summary Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV).
Chronic viral hepatitis C is asymptomatic for many years and can lead to the development of …
Chronic viral hepatitis C is asymptomatic for many years and can lead to the development of …
Research and application of local drug delivery system in promoting fracture healing
Y Jia, M Duan, Z Tang - Chinese Journal of Tissue Engineering Research, 2023 - cjter.com
BACKGROUND: Due to the unique anatomical and physiological characteristics of bone
and the dose dependence of osteogenic drugs, the local drug delivery system in fracture …
and the dose dependence of osteogenic drugs, the local drug delivery system in fracture …