Cells are continuously subjected to DNA damaging agents. DNA damages are repaired by
one of the many pathways guarding genomic integrity. When one or several DNA damage …

To improve the performance of yeast cell factories for industrial production, extensive
CRISPR-mediated genome editing systems have been applied by artificially creating double …

In metazoans mitochondrial DNA (mtDNA) or retrotransposon cDNA released to cytoplasm
are degraded by nucleases to prevent sterile inflammation. It remains unknown whether …

For Aspergillus flavus, a pathogen of considerable economic and health concern, successful
gene knockout work for more than a decade has relied nearly exclusively on using …

Developing more robust and productive industrial yeast is crucial for high-efficiency
biomanufacturing. However, the challenges posed by the long time required and the low …

Non-homologous end joining (NHEJ) and homologous recombination (HR) are the two
major pathways of DNA double-strand break (DSB) repair and both are highly conserved …

In recent years, eukaryotic microorganisms have been widely applied to offer many solutions
for everyday life and have come to play important roles in agriculture, food, health care, and …

There are two major pathways for repairing DNA double-strand breaks (DSBs): homologous
directed recombination (HDR) and non-homologous end-joining (NHEJ). While NHEJ …

Nucleotide excision repair (NER) is responsible for removing a wide variety of bulky adducts
from DNA, thus contributing to the maintenance of genome stability. The efficiency with …

Genomic integrity is most threatened by double-strand breaks, which, if left unrepaired, lead
to carcinogenesis or cell death. The cell generates a network of protein–protein signaling …