Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …

Background: The US EPA's Endocrine Disruptor Screening Program (EDSP) screens and
tests environmental chemicals for potential effects in estrogen, androgen, and thyroid …

A growing number of environmental pollutants are known to adversely affect the thyroid
hormone system, and major gaps have been identified in the tools available for the …

Background: It has been estimated that a substantial portion of chronic and
noncommunicable diseases can be caused or exacerbated by exposure to environmental …

Abstract The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and
communication tool to facilitate the transparent translation of mechanistic information into …

Increasing industrial and agricultural activities have led to a disturbing increase of pollutant
discharges into the environment. Most of these pollutants can induce short-term, sustained …

Trenbolone acetate is widely used in some parts of the world for its desirable anabolic
effects on livestock. Several metabolites of the acetate, including 17β‐trenbolone, have …

Screening and testing of potential endocrine‐disrupting chemicals for ecological effects are
examples of risk assessment/regulatory activities that can employ adverse outcome …

Human pharmaceuticals are extensively studied and assessed before marketing approval.
Since 2006, this also includes an assessment of environmental risks. In the European …

Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with
hormones in the body's endocrine systems and have been associated with a diverse array of …