[HTML][HTML] Nasopharyngeal carcinoma ecology theory: Cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem

W Luo - Theranostics, 2023 - ncbi.nlm.nih.gov
Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that is generally
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …

Latency and lytic replication in Epstein–Barr virus-associated oncogenesis

C Münz - Nature Reviews Microbiology, 2019 - nature.com
Epstein–Barr virus (EBV) was the first tumour virus identified in humans. The virus is
primarily associated with lymphomas and epithelial cell cancers. These tumours express …

Molecular mechanisms of viral oncogenesis in humans

NA Krump, J You - Nature Reviews Microbiology, 2018 - nature.com
Viral infection is a major contributor to the global cancer burden. Recent advances have
revealed that seven known oncogenic viruses promote tumorigenesis through shared host …

EBV persistence—introducing the virus

DA Thorley-Lawson - Epstein Barr Virus Volume 1: One Herpes Virus …, 2015 - Springer
Persistent infection by EBV is explained by the germinal center model (GCM) which provides
a satisfying and currently the only explanation for EBVs disparate biology. Since the GCM …

Epstein–Barr virus latent genes

MS Kang, E Kieff - Experimental & molecular medicine, 2015 - nature.com
Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

Epstein–Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infection

P Mrozek-Gorska, A Buschle, D Pich… - Proceedings of the …, 2019 - National Acad Sciences
Epstein–Barr virus (EBV) is a human tumor virus and a model of herpesviral latency. The
virus efficiently infects resting human B lymphocytes and induces their continuous …

Virus DNA replication and the host DNA damage response

MD Weitzman, A Fradet-Turcotte - Annual review of virology, 2018 - annualreviews.org
Viral DNA genomes have limited coding capacity and therefore harness cellular factors to
facilitate replication of their genomes and generate progeny virions. Studies of viruses and …

The viral and cellular microRNA targetome in lymphoblastoid cell lines

RL Skalsky, DL Corcoran, E Gottwein, CL Frank… - PLoS …, 2012 - journals.plos.org
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell
cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral …

Epstein-barr-virus-induced one-carbon metabolism drives B cell transformation

LW Wang, H Shen, L Nobre, I Ersing, JA Paulo… - Cell metabolism, 2019 - cell.com
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas.
How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely …

Role of viruses in the pathogenesis of multiple sclerosis

RE Tarlinton, E Martynova, AA Rizvanov… - Viruses, 2020 - mdpi.com
Multiple sclerosis (MS) is an immune inflammatory disease, where the underlying etiological
cause remains elusive. Multiple triggering factors have been suggested, including …