Stroke is a leading cause of disability. While neurotechnology has shown promise for
improving upper limb recovery after stroke, efficacy in clinical trials has been variable. Our …

The study of the cortical control of movement experienced a conceptual shift over recent
decades, as the basic currency of understanding shifted from single-neuron tuning towards …

Although the generation of movements is a fundamental function of the nervous system, the
underlying neural principles remain unclear. As flexor and extensor muscle activities …

The human brain is a complex, adaptive system comprised of billions of cells with trillions of
connections. The interactions between the elements of the system oppose this seemingly …

Neural activity is often described in terms of population-level factors extracted from the
responses of many neurons. Factors provide a lower-dimensional description with the aim of …

Neurons in frontal cortex exhibit diverse selectivity representing sensory, motor and
cognitive variables during decision-making. The neural circuit basis for this complex …

While motor cortical circuits contain information related to specific movement parameters,
long-range inputs also have a critical role in action execution,. Thalamic projections can …

Across a range of motor and cognitive tasks, cortical activity can be accurately described by
low-dimensional dynamics unfolding from specific initial conditions on every trial. These" …

Sequence memory is an essential attribute of natural and artificial intelligence that enables
agents to encode, store, and retrieve complex sequences of stimuli and actions …

Biological brains possess an unparalleled ability to adapt behavioral responses to changing
stimuli and environments. How neural processes enable this capacity is a fundamental open …