The updated landscape of tumor microenvironment and drug repurposing

MZ Jin, WL Jin - Signal transduction and targeted therapy, 2020 - nature.com
Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

[HTML][HTML] Links between thyroid disorders and glucose homeostasis

YS Eom, JR Wilson, VJ Bernet - Diabetes & Metabolism Journal, 2022 - ncbi.nlm.nih.gov
Thyroid disorders and diabetes mellitus often coexist and are closely related. Several
studies have shown a higher prevalence of thyroid disorders in patients with diabetes …

[HTML][HTML] Review of factors contributing to nodular goiter and thyroid carcinoma

I Yildirim Simsir, S Cetinkalp, T Kabalak - Medical Principles and …, 2020 - karger.com
There is an increased incidence of thyroid nodules and cancer. In this article, the reasons for
this increase are evaluated and discussed. The factors causing increases in the incidence of …

Metformin and risk of cancer among patients with type 2 diabetes mellitus: A systematic review and meta-analysis

K Zhang, P Bai, H Dai, Z Deng - Primary care diabetes, 2021 - Elsevier
Aim We carried out this meta-analysis on all published studies to estimate the overall cancer
risk of the use of metformin in T2DM patients. Methods We searched the PubMed, Embase …

[HTML][HTML] Metformin: current clinical applications in nondiabetic patients with cancer

K Chen, Y Li, Z Guo, Y Zeng, W Zhang… - Aging (Albany NY …, 2020 - ncbi.nlm.nih.gov
Metformin is one of the most commonly used first-line oral medications for type 2 diabetes
mellitus. Multiple observational studies, reviewed in numerous systematic reviews, have …

[HTML][HTML] Big data research in the field of endocrine diseases using the Korean National Health Information Database

SW Cho, JH Kim, HS Choi, HY Ahn… - Endocrinology and …, 2023 - synapse.koreamed.org
Abstract The Korean National Health Information Database (NHID) contains big data
combining information obtained from the National Health Insurance Service and health …

[HTML][HTML] Associations between diabetes mellitus and selected cancers

M Pliszka, L Szablewski - International Journal of Molecular Sciences, 2024 - mdpi.com
Cancer is one of the major causes of mortality and is the second leading cause of death.
Diabetes mellitus is a serious and growing problem worldwide, and its prevalence continues …

Thyroid cancer and insulin resistance

G Brenta, F Di Fermo - Reviews in Endocrine and Metabolic Disorders, 2024 - Springer
Thyroid cancer has shown a parallel increase with diabetes in the last few years. This
narrative review aims to explain the association between these two entities, focusing on …

Obesity, obesity-related metabolic conditions, and risk of thyroid cancer in women: results from a prospective cohort study (Sister Study)

E Pasqual, K O'Brien, S Rinaldi, DP Sandler… - The Lancet Regional …, 2023 - thelancet.com
Background Thyroid cancer incidence has increased worldwide. Obesity trends may play a
role, but the underlying biological pathways are not well-characterized. Therefore, we …

The role of an anti-diabetic drug metformin in the treatment of endocrine tumors

S Thakur, B Daley… - Journal of molecular …, 2019 - jme.bioscientifica.com
Incidence of endocrine cancers is rising every year. Over the last decade, evidence has
accumulated that demonstrates the anti-cancer effects of an anti-diabetic drug-metformin-in …