Serotonergic psychedelics, such as psilocybin and LSD, have garnered significant attention
in recent years for their potential therapeutic effects and unique mechanisms of action …

Classical psychedelics are a group of drugs characterized by their activation of the serotonin-
2A (5-hydroxytryptamine-2A; 5-HT2A) receptor and the unique hallucinogenic and mystical …

Background: Meta-analysis of randomized studies using lysergic acid diethylamide (LSD) for
alcohol use disorder (AUD) showed large, significant effects for LSD efficacy compared to …

Background Observational data and preliminary studies suggest serotonin 2A agonist
psychedelics may hold potential in treating a variety of substance use disorders (SUDs) …

Classic psychedelics refer to substances such as lysergic acid diethylamide (LSD),
psilocybin, ayahuasca, and mescaline, which induce altered states of consciousness by …

Ayahuasca is a hallucinogenic/psychedelic traditionally used for ritual and therapeutic
purposes. One such therapeutic use is related to Substance Use Disorders (SUDs). A …

Psychedelic-assisted psychotherapy holds great promise in the treatment of mental health
disorders. Research into 5-hydroxytryptamine 2A receptor (5-HT 2A R) agonist psychedelic …

Stress is known to alter GABAergic signaling in the ventral tegmental area (VTA), and this
inhibitory plasticity is associated with increased alcohol self-administration. In humans …

The relative value of and motivation for abused drugs often increases with drug experience
and differs based on drug availability. Here, we determined how different intake patterns of …

According to the opponent-process theory of drug addiction, the intake of an addictive
substance initiates two processes: a rapid primary process that results in the drug's …