Hereditary fibrinogen abnormalities comprise two classes of plasma fibrinogen defects: Type
I, afibrinogenemia or hypofibrinogenemia, which has absent or low plasma fibrinogen …

By the use of a fluorogenic thrombin substrate and continuous calibration of each individual
sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in …

Thrombin is the central enzyme in the coagulation cascade. Estimation of an individual's
potential to generate thrombin may correlate more closely with a hyper‐or hypo‐coagulable …

We analysed changes in coagulation during normal pregnancy with a novel point-of-care
device based on thrombelastometry (ROTEM®). We compared the results obtained with …

Perioperative coagulation monitoring is the rational diagnostic basis for pro-and anti-
thrombotic interventions in patients undergoing emergency and elective surgery. The main …

Understanding the mechanism of action of normal hemostasis and how the bypassing
agents recombinant activated factor VII (rFVIIa; NovoSeven) and plasma‐derived activated …

Introduction Discrepancies have been previously reported for one‐stage clotting and
chromogenic assays for FVIII activity analysis. Inter‐laboratory variations in instruments …

The bypassing agents factor eight inhibitor bypassing activity (FEIBA) anti‐inhibitor
coagulant complex and recombinant activated factor VII (rFVIIa) have been established as …

Peri‐operative anaemia, blood loss and allogeneic blood transfusion are associated with
increased postoperative morbidity and mortality, and prolonged hospital stay. A …

Future transfusion strategies are based on early and continuous assessment of the bleeding
and coagulation status of trauma patients. This allows specific and goal-directed treatment …