Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics

TJ Cahill, RP Choudhury, PR Riley - Nature Reviews Drug Discovery, 2017 - nature.com
Current therapies for heart failure after myocardial infarction are limited and non-curative.
Although regenerative approaches are receiving significant attention, clinical efforts that …

Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types

E Cambria, FS Pasqualini, P Wolint, J Günter… - NPJ Regenerative …, 2017 - nature.com
Acute myocardial infarction and chronic heart failure rank among the major causes of
morbidity and mortality worldwide. Except for heart transplantation, current therapy options …

Mesenchymal stem cell transplantation after acute myocardial infarction: a meta-analysis of clinical trials

A Attar, F Bahmanzadegan Jahromi, S Kavousi… - Stem Cell Research & …, 2021 - Springer
Background Trials investigating the role of mesenchymal stem cells (MSCs) in increasing
ejection fraction (LVEF) after acute myocardial infarction (AMI) have raised some …

Global position paper on cardiovascular regenerative medicine

F Fernández-Avilés, R Sanz-Ruiz… - European heart …, 2017 - academic.oup.com
Based on the increasingly understood regenerative capacity of the human heart and
vascular system, 1 cardiovascular regenerative medicine (CRM) encompasses all potential …

Injectable AuNP-HA matrix with localized stiffness enhances the formation of gap junction in engrafted human induced pluripotent stem cell-derived cardiomyocytes …

H Li, B Yu, P Yang, J Zhan, X Fan, P Chen, X Liao… - Biomaterials, 2021 - Elsevier
Cell therapy offers a promising paradigm for heart tissue regeneration. Human induced
pluripotent stem cells (hiPS) and their cardiac derivatives are emerging as a novel treatment …

Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial

KC Wollert, GP Meyer, J Müller-Ehmsen… - European heart …, 2017 - academic.oup.com
Aims Intracoronary infusion of autologous nucleated bone marrow cells (BMCs) enhanced
the recovery of left ventricular ejection fraction (LVEF) after ST-segment elevation …

Therapeutic use of stem cells for myocardial infarction

M Madigan, R Atoui - Bioengineering, 2018 - mdpi.com
Myocardial infarction is a leading cause of morbidity and mortality worldwide. Although
medical and surgical treatments can significantly improve patient outcomes, no treatment …

Concise review: optimized strategies for stem cell-based therapy in myocardial repair: clinical translatability and potential limitation

R Wu, X Hu, J Wang - Stem Cells, 2018 - academic.oup.com
Ischemic heart diseases (IHDs) remain major public health problems with high rates of
morbidity and mortality worldwide. Despite significant advances, current therapeutic …

Mid-to long-term efficacy and safety of stem cell therapy for acute myocardial infarction: a systematic review and meta-analysis

H Lee, HJ Cho, Y Han, SH Lee - Stem Cell Research & Therapy, 2024 - Springer
Background This comprehensive systematic review and meta-analysis investigated the mid-
to long-term efficacy and safety of stem cell therapy in patients with acute myocardial …

Stem cell therapies in cardiovascular disease

M Terashvili, ZJ Bosnjak - Journal of cardiothoracic and vascular …, 2019 - Elsevier
Despite considerable advances in medicine, cardiovascular disease is still rising, with
ischemic heart disease being the leading cause of death and disability worldwide. Thus …