Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo
To determine how neuronal circuits encode and drive behavior, it is often necessary to
measure and manipulate different aspects of neurochemical signaling in awake animals …
measure and manipulate different aspects of neurochemical signaling in awake animals …
Contribution of hypothalamic orexin (hypocretin) circuits to pathologies of motivation
A Mohammadkhani, C Mitchell… - British Journal of …, 2024 - Wiley Online Library
The orexin (also known as hypocretin) system, consisting of neuropeptides orexin‐A and
orexin‐B, was discovered over 25 years ago and was immediately identified as a central …
orexin‐B, was discovered over 25 years ago and was immediately identified as a central …
A chemogenetic approach for dopamine imaging with tunable sensitivity
MA Labouesse, M Wilhelm, Z Kagiampaki… - Nature …, 2024 - nature.com
Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release,
but their ability to detect a wide range of extracellular DA levels, especially tonic versus …
but their ability to detect a wide range of extracellular DA levels, especially tonic versus …
A biomimetic C-terminal extension strategy for photocaging amidated neuropeptides
Photoactivatable neuropeptides offer a robust stimulus–response relationship that can drive
mechanistic studies into the physiological mechanisms of neuropeptidergic transmission …
mechanistic studies into the physiological mechanisms of neuropeptidergic transmission …
Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
The glucagon-like peptide-1 receptor (GLP1R) is a broadly expressed target of peptide
hormones with essential roles in energy and glucose homeostasis, as well as of the …
hormones with essential roles in energy and glucose homeostasis, as well as of the …
International union of basic and clinical pharmacology CXIV: Orexin receptor function, nomenclature and pharmacology
The orexin system consists of the peptide transmitters orexin-A and-B and the G protein-
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …
Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery
Oxytocin is a neuropeptide critical for maternal physiology and social behavior, and is
thought to be dysregulated in several neuropsychiatric disorders. Despite the biological and …
thought to be dysregulated in several neuropsychiatric disorders. Despite the biological and …
[HTML][HTML] Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling
Beta-adrenergic receptors (βARs) are G protein-coupled receptors (GPCRs) that mediate
catecholamine hormone-induced stress responses, such as elevation of heart rate. Besides …
catecholamine hormone-induced stress responses, such as elevation of heart rate. Besides …
In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
D Prischich, R Sortino, A Gomila-Juaneda… - Cellular and Molecular …, 2024 - Springer
Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite.
Their dysfunction has been associated with sleeping disorders, and non-peptide drugs are …
Their dysfunction has been associated with sleeping disorders, and non-peptide drugs are …